Sort   by:  
 Page size 
TranscriptomicsRole and function of Bcor in BCR-ABL1 driven pre-B cells
In order to investigate the function of Bcor in ALL, we isolated bone marrow cells from Bcor fl/Y mice and transformed them with BCR-ABL1. In a second transduction the BCR-ABL1 driven pre-B cells were transformed either with CRE-ERT2 or ERT2 (PMIP) and after 2 days of treatment with 4OH-Tamoxifen (0...
ORGANISM(S): Mus musculus 
2013-06-03 | E-GEOD-34835 | biostudies-arrayexpress
TranscriptomicsRole and function of SPRY1/2 in BCR-ABL1 driven pre-B cells
In order to investigate the function of SPRY1 and SPRY2 in ALL, we isolated bone marrow cells from Spry1 and 2 fl/fl mice and transformed them with BCR-ABL1. In a second transduction the BCR-ABL1 driven pre-B cells were transformed either with CRE-ERT2 or ERT2 (PMIP) and after 2 days of treatment w...
ORGANISM(S): Mus musculus 
2013-06-03 | E-GEOD-34834 | biostudies-arrayexpress
TranscriptomicsRole and function of Pten in BCR-ABL1 driven pre-B cells
In order to investigate the function of Pten in ALL, we isolated bone marrow cells from Pten fl/fl mice and transformed them with BCR-ABL1. In a second transduction the BCR-ABL1 driven pre-B cells were transformed either with CRE-ERT2 or ERT2 (PMIP) and after 2 days of treatment with 4OH-Tamoxifen (...
ORGANISM(S): Mus musculus 
2013-06-03 | E-GEOD-34829 | biostudies-arrayexpress
TranscriptomicsRole and function of Ptpn6 in BCR-ABL1 driven pre-B cells
In order to investigate the function of Ptpn6 in ALL, we isolated bone marrow cells from Ptpn6 +/fl mice and transformed them with BCR-ABL1. In a second transduction the BCR-ABL1 driven pre-B cells were transformed either with CRE-ERT2 or ERT2 (PMIP) and after 2 days of treatment with 4OH-Tamoxifen ...
ORGANISM(S): Mus musculus 
2013-06-03 | E-GEOD-34831 | biostudies-arrayexpress
TranscriptomicsGene expression data of BCR-ABL1 transformed B cell precursors from BCL6 wild-type and BCL6 knockout mice
To elucidate the mechanism of BCL6-mediated pre-B cell survival signaling, we investigated the gene expression pattern in BCR-ABL1-transformed BCL6+/+ and BCL6-/- B cell precursors. Pharmacological inhibition of BCR-ABL1 was performed with the BCR-ABL1 kinase inhibitor STI571 (Imatinib). BCR-ABL1 t...
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-20987 | biostudies-arrayexpress
TranscriptomicsGene expression data of interleukin-7-dependent and BCR-ABL1-transformed pre-B cells
This analysis focused on identifying factors that protect pre-B cells against DNA double strand break (DSB)-mediated DNA damage stress during pre-B cell differentiation. Differentiation of pre-B cells including immunoglobulin light chain gene recombination were performed by withdrawal of interleuki...
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-21664 | biostudies-arrayexpress
TranscriptomicsBCOR controls maintenance of haematopoietic stem cell quiescence and regulates myeloid cell proliferation and differentiation [Illumina]
BCOR is a component of a variant Polycomb group repressive complex 1 (PRC1) complex. Recently, we and others reported recurrent somatic BCOR loss-of-function mutations in myelodysplastic syndrome and acute myelogenous leukaemia (AML). However the role of BCOR in normal hematopoiesis is largely unkno...
ORGANISM(S): Mus musculus 
2015-12-31 | E-GEOD-69620 | biostudies-arrayexpress
TranscriptomicsBCOR controls maintenance of haematopoietic stem cell quiescence and regulates myeloid cell proliferation and differentiation [Affymetrix]
BCOR is a component of a variant Polycomb group repressive complex 1 (PRC1) complex. Recently, we and others reported recurrent somatic BCOR loss-of-function mutations in myelodysplastic syndrome and acute myelogenous leukaemia (AML). However the role of BCOR in normal hematopoiesis is largely unkno...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-69565 | biostudies-arrayexpress
Sort   by:  
 Page size