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ProteomicsShort duplex RNAs induce potent immunostimulation via Hoogsteen G-G base pairing-mediated dimerization
Here we describe a new class of immunostimulatory short duplex RNAs that potently induce production of type I interferon (IFN-I), and particularly IFN-β, in a wide range ofhuman cell types via end-to-end dimerization, direct binding to RIG-I, and activation of the RIG-I/IRF3 pathway. These RNAs requ...
ORGANISM(S): Homo sapiens (Human) 
2022-09-01 | PXD027838 | Pride
Type i interferon Lung chips Sars-cov-2 Immune stimulation Short duplex rna 
GenomicsShort duplex RNAs induce potent immunostimulation via Hoogsteen G-G base pairing-mediated dimerization
Short duplex RNAs induce potent immunostimulation via Hoogsteen G-G base pairing-mediated dimerization
PRJNA753532 | ENA
UnknownHigh Bendability of Short RNA-DNA Hybrid Duplex Revealed by Single-Molecule Cyclization and Molecular Dynamics Simulations.
Not available
S-EPMC12109412 | biostudies-literature
TranscriptomicsSorting of Drosophila small silencing RNAs partitions microRNA* strands into the RNA interference pathway
In flies, small silencing RNAs are sorted between Argonaute1 (Ago1), the central protein component of the microRNA (miRNA) pathway, and Argonaute2 (Ago2), which mediates RNA interference. Extensive double-stranded characterM-bM-^@M-^Tas is found in small interfering RNAs (siRNAs)M-bM-^@M-^Tdirects d...
ORGANISM(S): Drosophila melanogaster 
2009-10-31 | E-GEOD-18806 | biostudies-arrayexpress
TranscriptomicsShort duplex RNAs induce potent immunostimulation via Hoogsteen G-G base pairing-mediated dimerization
Here we describe a new class of immunostimulatory short duplex RNAs that potently induce production of type I interferon (IFN-I), and particularly IFN-β, in a wide range of human cell types via end-to-end dimerization, direct binding to RIG-I, and activation of the RIG-I/IRF3 pathway. These RNAs req...
ORGANISM(S): Homo sapiens 
2021-08-12 | GSE181827 | GEO
UnknownAPOBEC3H structure reveals an unusual mechanism of interaction with duplex RNA.
Not available
S-EPMC5647330 | biostudies-literature
UnknownSelf-assembling short immunostimulatory duplex RNAs with broad spectrum antiviral activity.
Not available
S-EPMC8629196 | biostudies-literature
UnknownSelf-assembling short immunostimulatory duplex RNAs with broad-spectrum antiviral activity.
Not available
S-EPMC9398551 | biostudies-literature
UnknownEukaryotic RNases H1 act processively by interactions through the duplex RNA-binding domain.
Not available
S-EPMC1079969 | biostudies-literature
UnknownStructure and RNA recognition of ribosome assembly factor Utp30.
Not available
S-EPMC5689012 | biostudies-literature
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