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TranscriptomicsExpression data from ileum of inducible intestine-specific GATA6 knockout mice
GATA6 is a transcription factor involved in the differentiation of intestinal epithelial cells into differentiated absorptive epithelial cells. GATA6 is expressed in all segments of the small intestine. We examined the impact of deleting GATA6 from intestinal epithelial cells of the adult ileum 6-8...
ORGANISM(S): Mus musculus 
2011-06-07 | E-GEOD-22416 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression in intestinal mouse crypts after loss of KLF5
To determine potential targets of KLF5 we performed RNA-sequencing on jejunal crypts isolated from Klf5-deficient and wildtype mice, using three biological replicates per genotype. We identified 1,480 genes that showed significant differential expression with at least a 2-fold difference between Kl...
ORGANISM(S): Mus musculus 
2016-04-01 | E-GEOD-79758 | biostudies-arrayexpress
TranscriptomicsKruppel-like factor 5 is Required for Villus Formation and Terminal Differentiation of the Intestinal Epithelium
To identify putative KLF5 target genes that may mediate villus morphogenesis and epithelial maturation, we performed microarray analysis on intestinal samples isolated on E14.5, prior to the initiation of villus formation. Total RNA was isolated from dissected intestine segments located ~1.5 cm ant...
ORGANISM(S): Mus musculus 
2013-01-24 | E-GEOD-39624 | biostudies-arrayexpress
TranscriptomicsRNA-seq comparison of gene expression in enteroids derived of fresh or frozen human intestinal biopsies
Background & Aims Patient-derived gastrointestinal organoids are powerful tools for studying human physiology and disease. However, generating organoids requires prompt isolation and culture of fresh tissue, which is labor and time intensive, placing restraints on basic and clinical research. For ex...
ORGANISM(S): Homo sapiens 
2018-06-30 | E-MTAB-6516 | biostudies-arrayexpress
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