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TranscriptomicsMechanisms for U2AF to define 3M-bM-^@M-2 splice sites and regulate alternative splicing in the human genome
The U2AF heterodimer has been well studied for its role in defining functional 3M-bM-^@M-^Y splice sites in pre-mRNA splicing, but many fundamental questions still remain unaddressed regarding the function of U2AF in mammalian genomes. Through genome-wide analysis of U2AF-RNA interactions, we report...
ORGANISM(S): Homo sapiens 
2014-10-08 | E-GEOD-61603 | biostudies-arrayexpress
TranscriptomicsGene expression profiling analysis of nasopharyngeal carcinoma cell CNE1/MTA1-si cells and CNE1 cells
Investigation of whole genome gene expression level changes in MTA1-silencing CNE1 cells, compared to the wild-type CNE1 cell. A double chip study using total RNA recovered from two cell lines, CNE1/MTA1-si cells and CNE1 cells. Each chip measures the expression level of 45,033 genes from human.
ORGANISM(S): Homo sapiens 
2012-09-14 | E-GEOD-40858 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of MCF-7 cells treated with Si-Wu-Tang, estradiol and ferulic acid
Traditional Chinese medicines (TCM), usually composed of a mixture of components, may simultaneously target multiple genes/pathways and thus achieve superior efficacy for complex diseases such as cancer. To identify novel mechanisms of action and potential health benefits for a TCM formula Si-Wu-Tan...
ORGANISM(S): Homo sapiens 
2011-05-18 | E-GEOD-23610 | biostudies-arrayexpress
TranscriptomicsExpression data from immortalized human lung small airway epithelial cells
In lung cancer progression, p53 mutations are more often observed in invasive tumors than in non-invasive tumors, suggesting that p53 is involved in tumor invasion and metastasis. To understand the nature of p53 function as a tumor suppressor, it is crucial to elucidate the detailed mechanism of the...
ORGANISM(S): Homo sapiens 
2013-05-29 | E-GEOD-47436 | biostudies-arrayexpress
TranscriptomicsIdentification of genes essential for Moraxella catarrhalis growth under iron-limiting conditions using Genomic Array Footprinting (GAF): Expression analysis of directed gene deletion mutants.
Iron-sequestration by the human host is a first line defense against respiratory pathogens like Moraxella catarrhalis, which consequently experiences a period of iron-starvation during colonization and infection. We determined the genetic requirements for M. catarrhalis growth during iron-starvation...
ORGANISM(S): Moraxella catarrhalis BBH18 
2013-06-06 | E-GEOD-41547 | biostudies-arrayexpress
TranscriptomicsIdentification of genes essential for Moraxella catarrhalis growth under iron-limiting conditions using Genomic Array Footprinting (GAF)
Iron-sequestration by the human host is a first line defense against respiratory pathogens like Moraxella catarrhalis, which consequently experiences a period of iron-starvation during colonization and infection. We determined the genetic requirements for M. catarrhalis growth during iron-starvation...
ORGANISM(S): Moraxella catarrhalis BBH18 
2013-06-06 | E-GEOD-41546 | biostudies-arrayexpress
TranscriptomicsDifferentiation of human embryonic stem cells towards hepatocytes
To understand in detail the molecular phases that occur during the differentiation of human embryonic stem cells to hepatocyte-like cells we performed an RNA-seq time course of the stages of differentiation across the 21 day differentiation time course. We used a chemically defined (serum-free) prot...
ORGANISM(S): Homo sapiens 
2017-04-28 | E-GEOD-70741 | biostudies-arrayexpress
TranscriptomicsTumor Cell Survival Dependence on the DExH-Box Helicase DHX9
The ATP-dependent DExH/D-box helicase DHX9 is a key participant in a number of gene regulatory steps, including transcriptional, translational, microRNA-mediated control, DNA replication, and maintenance of genomic stability. DHX9 has also been implicated in maintenance of the tumorigenic process an...
ORGANISM(S): Mus musculus 
2016-05-19 | E-GEOD-76765 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression profiling of small-intestine neuroendocrine tumors and human neuroendocrine tumor cell lines
Small intestinal neuroendocrine tumors (SI-NETs) arise from serotonin-producing enterochromaffin cells. SI-NETs are often well-differentiated tumors and most patients have regional or distant metastases at initial presentation. MicroRNAs (miRs) are post-transcriptional regulators which are important...
ORGANISM(S): Homo sapiens 
2013-03-01 | E-GEOD-33568 | biostudies-arrayexpress
TranscriptomicsRNA helicases DDX5 and DDX17 dynamically orchestrate transcription, microRNA and splicing programs in cell differentiation
RNA helicases DDX5 and DDX17 are members of a large family of highly conserved proteins involved in gene expression regulation, although their in vivo targets and activities in biological processes like cell differentiation, that requires reprogramming of gene expression programs at multiple levels,...
ORGANISM(S): Homo sapiens 
2014-05-06 | E-GEOD-57281 | biostudies-arrayexpress
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