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TranscriptomicsGene expression profile of mouse breast cancer V720 cells treated with vehicle or PD 0332991
D-cyclins represent components of cell cycle machinery. To test the efficacy of targeting D-cyclins in cancer treatment, we engineered mouse strains which allow acute and global ablation of individual D-cyclins in a living animal. Ubiquitous shutdown of cyclin D1 or inhibition of cyclin D associated...
ORGANISM(S): Mus musculus 
2012-10-16 | E-GEOD-40513 | biostudies-arrayexpress
TranscriptomicsCyclin D:Cdk4/6 Activates Rb in Early G1 Phase by Mono-Phosphorylation
The retinoblastoma tumor suppressor protein (Rb) regulates early G1 phase checkpoints, including the DNA damage response, as well as cell cycle exit and differentiation. The widely accepted model of G1 cell cycle progression proposes that cyclin D:Cdk4/6 partially inactivates the Rb tumor suppresso...
ORGANISM(S): Mus musculus 
2014-04-03 | E-GEOD-56453 | biostudies-arrayexpress
Proteomics,MultiomicsCyclin C-CDK3/8/19 kinases play a tumor-suppressive role in vivo
Cyclin C was cloned as a growth-promoting G1 cyclin1,2, and several studies postulated a role for cyclin C in driving cell proliferation3-8 . Moreover, cyclin C, together with its kinase partner, the cyclin-dependent kinase CDK8, is believed to represent an essential component of basal transcrip...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080728 | MassIVE
TranscriptomicsGene expression profile of human T-ALL cell line KOPTK1 treated with vehicle or PD 0332991
D-cyclins represent components of cell cycle machinery. To test the efficacy of targeting D-cyclins in cancer treatment, we engineered mouse strains which allow acute and global ablation of individual D-cyclins in a living animal. Ubiquitous shutdown of cyclin D1 or inhibition of cyclin D associated...
ORGANISM(S): Homo sapiens 
2012-10-16 | E-GEOD-40512 | biostudies-arrayexpress
TranscriptomicsThe Requirement for Cyclin D Function in Tumor Maintenance
This SuperSeries is composed of the following subset Series: GSE40512: Gene expression profile of human T-ALL cell line KOPTK1 treated with vehicle or PD 0332991 GSE40513: Gene expression profile of mouse breast cancer V720 cells treated with vehicle or PD 0332991 Refer to individual Series
ORGANISM(S): Mus musculus 
2012-10-16 | E-GEOD-40514 | biostudies-arrayexpress
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