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ProteomicsTEAD inhibitor K-975 enhances KRASG12C inhibitor adagrasib-mediated cancer cell proliferation inhibition via dual cell cycle arrest
Here we investigate the effect of the dual inhibition, in KRASG12C mutated NSCLC cells, using the KRASG12Ci adagrasib (MRTX849) and the pan-TEAD inhibitor (TEADi) K-975. We show that K-975 enhances adagrasib-induced tumor cell growth inhibition in cancer cells. Mechanistically, we detect a downregul...
ORGANISM(S): Homo Sapiens (human) 
2023-05-12 | PXD039726 | JPOST Repository
UnknownComparison of predicted amino acid sequences of measles virus strains in the Edmonston vaccine lineage.
Not available
S-EPMC113987 | biostudies-literature
UnknownEarly postoperative paclitaxel followed by concurrent paclitaxel and cisplatin with radiation therapy for patients with resected high-risk head and neck squamous cell carcinoma: report of the phase II trial RTOG 0024.
Not available
S-EPMC2754914 | biostudies-literature
TranscriptomicsBacillus anthracis' lethal toxin induces broad transcriptional responses in human peripheral monocyte.
Anthrax lethal toxin directly targets human peripheral monocytes and causes multiple aberrant gene responses that would be expected to result in defects in human monocyteM-bM-^@M-^Ys normal signaling transduction pathways and nction. This study provides further insights into the mechanisms associate...
ORGANISM(S): Homo sapiens 
2012-12-12 | E-GEOD-34407 | biostudies-arrayexpress
TranscriptomicsHuman embryonic stem cells differentiated in dopaminergic neurons
Human embryonic stem cells have been a great interest due to its potential to provide a renewable source of surrogate dopamine neurons for transplantation into ParkinsonM-bM-^@M-^Ys disease patients. We have differentiated hESCs with a monolayer of PA6 cells under 2D and 3D systems for 28 days. Geno...
ORGANISM(S): Homo sapiens 
2013-01-03 | E-GEOD-43235 | biostudies-arrayexpress
UnknownComparative Transcriptomics Sheds Light on Remodeling of Gene Expression during Diazotrophy in the Thermophilic Methanogen Methanothermococcus thermolithotrophicus.
Not available
S-EPMC9765008 | biostudies-literature
UnknownActivity and toxicity of intramuscular 1000 iu/m2 polyethylene glycol-E. coli L-asparaginase in the UKALL 2003 and UKALL 2011 clinical trials.
Not available
S-EPMC9314843 | biostudies-literature
UnknownRNF114 and RNF166 exemplify reader-writer E3 ligases that extend K11 polyubiquitin onto sites of MARUbylation
Not available
S-SCDT-10_1038-S44318-025-00577-Z | biostudies-other
MetabolomicsNPC1 regulates the distribution of phosphatidylinositol 4 kinases at Golgi and Lysosome membranes
Cholesterol and phosphoinositides (PI) are two critically important lipids that are found in cellular membranes and dysregulated in many disorders. Therefore, uncovering molecular pathways connecting these essential lipids may offer new therapeutic insights. We report that loss of function of lysoso...
2021-09-15 | MTBLS2612 | MetaboLights
UnknownEffect of meloxicam and lidocaine administered alone or in combination on indicators of pain and distress during and after knife castration in weaned beef calves.
Not available
S-EPMC6269141 | biostudies-literature
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