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TranscriptomicsRegulation of Transcription Termination by Glucosylated Hydroxymethyluracil, Base J, in L. major and T. brucei
Base J, β-D-glucosyl-hydroxymethyluracil, is an epigenetic modification of thymine in the nuclear DNA of flagellated protozoa of the order Kinetoplastida. J is enriched at sites involved in RNA Polymerase (RNAP) II initiation and termination. We have previously demonstrated a role of J in regulating...
ORGANISM(S): Trypanosoma brucei 
2015-05-18 | E-GEOD-57621 | biostudies-arrayexpress
UnknownTotal synthesis of all (-)-Agelastatin alkaloids.
Not available
S-EPMC3016719 | biostudies-literature
UnknownSNARE proteins rescue impaired autophagic flux in Down syndrome.
Not available
S-EPMC6850524 | biostudies-literature
TranscriptomicsEfficacy of carboplatin alone and in combination with ABT888 in intracranial murine models of BRCA-mutated and BRCA-wild-type triple negative breast cancer
Purpose:Triple negative breast cancer (TNBC) commonly metastasizes to the brain and predicts poor prognosis with limited therapeutic options. TNBC frequently harbors BRCA mutations translating to platinum sensitivity; platinum response may be augmented by additional suppression of DNA repair mechani...
ORGANISM(S): Homo sapiens 
2015-05-12 | E-GEOD-55399 | biostudies-arrayexpress
UnknownEarly High-Dose Vitamin D3 for Critically Ill, Vitamin D-Deficient Patients.
Not available
S-EPMC7306117 | biostudies-literature
UnknownSynthesis and anticancer activity of all known (-)-agelastatin alkaloids.
Not available
S-EPMC3920459 | biostudies-literature
UnknownRedox modulation of NQO1.
Not available
S-EPMC5752044 | biostudies-literature
MetabolomicsCoupled Mass-Spectrometry-Based Lipidomics Machine Learning Approach for Early Detection of Clear Cell Renal Cell Carcinoma

A discovery-based lipid profiling study of serum samples from a cohort that included patients with clear cell Renal Cell Carcinoma (ccRCC) stage I, II, III, and IV (n=112) and controls (n=52) was performed using ultraperformance liquid chromatography coupled to quadrupole-time-of-flight mass spec...

2020-11-20 | MTBLS1839 | MetaboLights
UnknownPan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway.
Not available
S-EPMC7156427 | biostudies-literature
UnknownPhase 1b trial of isatuximab, an anti-CD38 monoclonal antibody, in combination with carfilzomib as treatment of relapsed/refractory multiple myeloma.
Not available
S-EPMC8252002 | biostudies-literature
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