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GenomicsDrosophila Gtsf1 is an essential component of the Piwi mediated transcriptional silencing complex
The PIWI interacting RNA pathway is a small RNA silencing system that keeps selfish genetic elements such as transposons under control in animal gonads. Several lines of evidence indicate that nuclear PIWI family proteins guide transcriptional silencing of their targets, yet the composition of the u...
ORGANISM(S): Drosophila melanogaster 
2013-09-06 | E-GEOD-48317 | biostudies-arrayexpress
TranscriptomicsTranscriptional silencing of transposable elements by Piwi and its impact on chromatin and gene expression
Eukaryotic genomes are colonized by transposable elements whose uncontrolled activity results in genomic instability. The piRNA pathway silences transposons in animal gonads, yet how this is achieved molecularly remains controversial. We assign an essential role to the HMG protein Maelstrom in the p...
ORGANISM(S): Drosophila melanogaster 
2012-11-26 | E-GEOD-41729 | biostudies-arrayexpress
TranscriptomicsThe Rhino-Deadlock-Cutoff complex licenses non-canonical transcription of dual-strand piRNA clusters in Drosophila
Argonaute proteins of the PIWI clade are central to transposon silencing in animal gonads. Their target specificity is defined by 22-30nt PIWI interacting RNAs (piRNAs), which mostly originate from discrete genomic loci termed piRNA clusters. Here we show that the RDC complex composed of Rhino, Dead...
ORGANISM(S): Drosophila melanogaster 
2014-06-08 | E-GEOD-55824 | biostudies-arrayexpress
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