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TranscriptomicsEssential functions for ID proteins at multiple checkpoints in natural killer T cell development
Thymic iNKT cell development is divided into four stages (stage 0-3) that are characterised, in C57BL/6 mouse strain, by the differential expression of surface markers, such as CD24, CD44 and NK1.1. During transition from immature to mature iNKT cell subsets, gene expression is tightly regulated. He...
ORGANISM(S): Mus musculus 
2013-11-19 | E-GEOD-50933 | biostudies-arrayexpress
GenomicsEstablishment of Enhancer Repertoires that Orchestrate the Myeloid and Lymphoid Cell Fates (ChIP-Seq dataset)
Recent studies have documented genome-wide binding patterns of transcriptional regulators and their associated epigenetic marks in hematopoietic cell lineages. In order to determine how epigenetic marks are established and maintained during developmental progression, we have generated long-term cult...
ORGANISM(S): Mus musculus 
2011-09-01 | E-GEOD-30858 | biostudies-arrayexpress
TranscriptomicsSingle cell analysis of the Common Lymphoid Progenitor compartment reveals functional and molecular heterogeneity
In order to investigate molecular events involved in the regulation of lymphoid lineage commitment, we crossed lamda5 reporter transgenic mice to mice where the GFP gene is inserted into the Rag1 locus. This allowed us to sub-fractionate common lymphoid progenitors (CLPs) and pre-pro-B cells into la...
ORGANISM(S): Mus musculus 
2009-11-24 | E-GEOD-19142 | biostudies-arrayexpress
TranscriptomicsExpression data from WT and E2A-deficient murine DN2 cells
The E2A transcription factors promote the development of thymus-seeding cells but it remains unknown whether these proteins play a role in T lymphocyte lineage specification or commitment. By examining E2A-dependent genes in developing T cells, we will address whether these proteins are involved in ...
ORGANISM(S): Mus musculus 
2013-02-01 | E-GEOD-43224 | biostudies-arrayexpress
TranscriptomicsA global network of transcription factors, involving E2A, EBF1 and FOXO1, that orchestrates the B cell fate
It is now established that the transcription factors E2A, EBF1 and FoxoM-BM- 1 play critical roles in B cell development. Here we show that E2A and EBF1 bound regulatory elements present in the Foxo1 locus. E2A and EBF1 as well as E2A and Foxo1, in turn, were wired together by a vast spectrum of cis...
ORGANISM(S): Mus musculus 
2010-06-12 | E-GEOD-21978 | biostudies-arrayexpress
TranscriptomicsAccumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes molecularly distinct from physiologic stem cell aging
Somatic stem cells mediate tissue maintenance for the lifetime of an organism. Despite the well-established longevity that is a prerequisite for such function, accumulating data argue for compromised stem cell function with age. Identifying the mechanisms underlying age-dependent stem cell dysfuncti...
ORGANISM(S): Mus musculus 
2011-05-06 | E-GEOD-27686 | biostudies-arrayexpress
TranscriptomicsInteractions between developing B-lymphocytes and stromal cells reveal complex interactions and two-way communication
Full title: Genomics based analysis of interactions between developing B-lymphocytes and stromal cells reveal complex interactions and two-way communication In order to identify extra cellular signals that promote B lymphocyte development we created a database with approximately 400 receptor ligand...
ORGANISM(S): Mus musculus 
2010-01-05 | E-GEOD-19729 | biostudies-arrayexpress
TranscriptomicsCombined heterozygous loss of Ebf1 and Pax5 allows for T-lineage conversion of B-cell progenitors
In order to investigate how transcription factor dose impacts B-lymphocyte development, we generated mice carrying transheterozygous mutations in the Pax5 and Ebf1 genes. While combined reduction of Pax5 and Ebf1 dose had minimal impact on the development of the earliest CD19+ progenitors, these cel...
ORGANISM(S): Mus musculus 
2015-05-27 | E-GEOD-69227 | biostudies-arrayexpress
TranscriptomicsExpression profiling of ProB and PreB cells in Ebf1 heterozygous mouse bone marrow
Loss of one allele of Ebf1 impairs pre-B cell (B220+CD19+CD43low/negIgM-) expansion. In order to better understand the underlying cause of the reduced pre-B cell compartment in Ebf1+/- mice, we sorted pro-B (B220+CD19+CD43highIgM- ) as well as pre-B cells from Wt and Ebf1 heterozygote mutant mice an...
ORGANISM(S): Mus musculus 
2013-10-18 | E-GEOD-51385 | biostudies-arrayexpress
TranscriptomicsEstablishment of Enhancer Repertoires that Orchestrate the Myeloid and Lymphoid Cell Fates (gene expression dataset 2)
Recent studies have documented genome-wide binding patterns of transcriptional regulators and their associated epigenetic marks in hematopoietic cell lineages. In order to determine how epigenetic marks are established and maintained during developmental progression, we have generated long-term cult...
ORGANISM(S): Mus musculus 
2011-08-31 | E-GEOD-30856 | biostudies-arrayexpress
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