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ProteomicsAP-MS analysis of sirtuin-4 interactions in human fibroblasts
Sirtuins (SIRTs) form a critical family of nicotinamide adenine dinucleotide (NAD)-dependent enzymes that govern genome regulation, metabolism, and aging. Despite conserved deacetylase domains, SIRTs4-7 have little to no deacetylase activity, and a robust catalytic activity for mitochondrial SIRT4 h...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-03-04 | MSV000079557 | MassIVE
ProteomicsInteracting proteomics of Toxoplasma gondii silent information regulator 2 (TgSIR2A)
The smHA tag was attached to the C-terminal of endogenous TgSIR2A, and the interacting proteins of TgSIR2A were identified by mass spectrometry before being enriched by HA magnetic beads.
ORGANISM(S): Toxoplasma gondii GT1 
2026-09-14 | PXD062403 | Pride
Tgsir2a Toxoplasma gondii Histone deacetylase Interaction Silent information regulator 2 
ProteomicsSirtuin 5 Reduces Malonylation in Non-mitochondrial Metabolic Pathways in Diabetic Kidney Disease
Early diabetic kidney disease (DKD) is marked by dramatic metabolic reprogramming due to nutrient excess, mitochondrial dysfunction, and increased renal energy requirements from hyperfiltration. We hypothesized that changes in metabolism in DKD may be regulated by Sirtuin 5 (SIRT5), a deacylase that...
ORGANISM(S): Mus Musculus 
2023-06-26 | PXD037819 | panorama
ProteomicsSCFCyclin F targets the metabolic protein Sirtuin 5 for ubiquitination
Cell cycle transitions are regulated by a number of coordinating signaling events. The ubiquitin-proteasome system is an important part of this cell cycle signaling. Cyclin F, a substrate adapter for the SCF (SKP1/CUL1/F-box) E3 ubiquitin ligase, is an important regulator of cell cycle progression. ...
ORGANISM(S): Homo Sapiens (human) 
2020-11-17 | PXD019396 | JPOST Repository
UnknownSilent information regulator 2 promotes clear cell renal cell carcinoma progression through deacetylation and small ubiquitin-related modifier 1 modification of glucose 6-phosphate dehydrogenase.
Not available
S-EPMC8486209 | biostudies-literature
UnknownSirtuin 2, a mammalian homolog of yeast silent information regulator-2 longevity regulator, is an oligodendroglial protein that decelerates cell differentiation through deacetylating alpha-tubulin.
Not available
S-EPMC6672490 | biostudies-literature
TranscriptomicsmicroRNA and aging
The critical role of the endothelium in governing vascular, tissues homeostasis and pathological processes is increasingly recognized (Deanfield et al., 2007). Cellular senescence of endothelial cells has been proposed to be involved in endothelial dysfunction and atherogenesis (Minamino T et al., 2...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-14912 | biostudies-arrayexpress
UnknownNeuronal SIRT1 (Silent Information Regulator 2 Homologue 1) Regulates Glycolysis and Mediates Resveratrol-Induced Ischemic Tolerance.
Not available
S-EPMC5654689 | biostudies-literature
UnknownExpression of silent mating type information regulator 2 homolog 1 and its role in human intervertebral disc cell homeostasis.
Not available
S-EPMC3334653 | biostudies-literature
UnknownThe crystal structure of the Leishmania infantum Silent Information Regulator 2 related protein 1: Implications to protein function and drug design.
Not available
S-EPMC5854310 | biostudies-literature
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