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TranscriptomicshHGF Overexpression in Myoblast Sheets Enhances Their Angiogenic Potential in Rat Chronic Heart Failure
Ischemia, fibrosis, and remodeling lead to heart failure after severe myocardial infarction (MI). Myoblast sheet transplantation is a promising therapy to enhance cardiac function and induce therapeutic angiogenesis via a paracrine mechanism in this detrimental disease. We hypothesized that in a rat...
ORGANISM(S): Rattus norvegicus 
2010-12-10 | E-GEOD-25752 | biostudies-arrayexpress
TranscriptomicsSkeletal myoblasts protect cardiomyocytes against oxidative stress via c-Met and epidermal growth factor receptor (EGFR)-dependent paracrine pathways
To study the effect of myoblast-derived paracrine factors on cardiomyocyte gene expression, microarray analysis was performed from isolated rat fetal cardiomyocyte cultures. These cultures were treated for 24 hours with fresh culture medium (control), skeletal myoblast-conditioned medium, or cardiac...
ORGANISM(S): Rattus norvegicus 
2012-01-28 | E-GEOD-35393 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of negative-pressure-treated split-thickness skin graft donor site wounds reveals novel effects on epithelialization
Negative-pressure wound therapy (NPWT) is widely used to improve skin wound healing and to accelerate wound bed preparation. Although NPWT has been extensively studied as a treatment for deep wounds, its effect on epithelialization of superficial dermal wounds remains unclear. To clarify the effect ...
ORGANISM(S): Homo sapiens 
2011-10-24 | E-GEOD-33169 | biostudies-arrayexpress
TranscriptomicsHuman Skin Transcriptome during Epidermal Wound Healing
In order to clarify the human response of re-epithelialization, we biopsied split-thickness skin graft donor site wounds immediately before and after harvesting, as well as during the healing process 3 and 7 days thereafter. Altogether 25 biopsies from 8 patients qualified for the study. All samples...
ORGANISM(S): Homo sapiens 
2011-04-29 | E-GEOD-28914 | biostudies-arrayexpress
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