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TranscriptomicsTranscriptional profiling of experimental CD8+ lymphocyte depletion in rhesus macaques infected with SIVmac239
CD8+ T-cells inhibit virus replication in SIV-infected rhesus macaques (RM). However, it is unclear to what extent the viral suppression mediated by CD8+ T-cells reflects direct killing of infected cells as opposed to indirect, non-cytolytic mechanisms. In this study, we used functional genomics to ...
ORGANISM(S): Macaca mulatta 
2013-02-08 | E-GEOD-37834 | biostudies-arrayexpress
TranscriptomicsGene expression profiling data from sooty mangabeys treated with interferon alpha
In contrast to pathogenic HIV and SIV infection of humans and macaques, SIV infection of sooty mangabeys (SMs) is typically non-pathogenic despite high virus replication. A key feature of primary SIV infection of SMs is a strong type I interferon (IFN-I) response, characterized by massive up-regulat...
ORGANISM(S): Cercocebus atys 
2012-07-09 | E-GEOD-35460 | biostudies-arrayexpress
TranscriptomicsDecreased TFR/TFH ratio in SIV-infected rhesus macaques may contribute to accumulation of TFH cells in chronic infection
T follicular helper cells (TFH) are critical for the development and maintenance of germinal centers (GC) and humoral immune responses. During chronic HIV/SIV infection TFH accumulate, possibly as a result of antigen persistence. The HIV/SIV-associated TFH expansion may also reflect lack of regulati...
ORGANISM(S): Macaca mulatta 
2015-09-02 | E-GEOD-69756 | biostudies-arrayexpress
TranscriptomicsCirculating Monocytes in HIV-1 infected Viremic Subjects Exhibit an Anti-Apoptotic Gene Signature
Mechanisms that may allow circulating monocytes to persist as CD4 T cells diminish in HIV-1 infection have not been investigated. We have characterized steady-state gene expression signatures in circulating monocytes from HIV-infected subjects and have identified a stable anti-apoptosis gene signatu...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-14542 | biostudies-arrayexpress
Unknown4-(5-Chloro-3-(3,4,5-trimethoxybenzoyl)-1H-indol-1-yl)benzenesulfonamide: A Novel Polypharmacology Agent to Target Carbonic Anhydrase IX and XII With Improved Selectivity, Wnt/β-Catenin Signaling Pathway, and P-Glycoprotein.
Not available
S-EPMC12935169 | biostudies-literature
TranscriptomicsMicroarray Expression Analysis of SIV infection of Sooty Mangabeys
Natural SIV infection of sooty mangabeys (SMs) does not progress to disease despite chronic virus replication. In contrast to pathogenic SIV infection of rhesus macaques (RMs), chronic SIV infection of SMs is characterized by low immune activation. To elucidate the mechanisms underlying this phenoty...
ORGANISM(S): Cercocebus torquatus atys 
2010-03-08 | E-GEOD-16147 | biostudies-arrayexpress
Unknown4-(3-Phenyl-4-(3,4,5-trimethoxybenzoyl)-1<i>H</i>-pyrrol-1-yl)benzenesulfonamide, a Novel Carbonic Anhydrase and Wnt/β-Catenin Signaling Pathway Dual-Targeting Inhibitor with Potent Activity against Multidrug Resistant Cancer Cells.
Not available
S-EPMC10641813 | biostudies-literature
TranscriptomicsType I IFN responses in rhesus macaques prevent SIV transmission and slow disease progression
In acute HIV infection immune activation may provide target cells and drive virus replication, which innate immunity may limit. Thus, the net effects of inflammatory mediators, including type I interferon (IFN-I), are unclear. Here, we block IFN-I signaling during pathogenic acute SIV infection wit...
ORGANISM(S): Macaca mulatta 
2014-07-23 | E-GEOD-53690 | biostudies-arrayexpress
TranscriptomicsComparative analysis of genomic features of human HIV-1 infection and primate models of SIV infection
High levels of HIV-1 replication during the chronic phase of infection are usually associated with rapid disease progression (RP). However, a minority of HIV-infected individuals remain asymptomatic and show persistently high CD4+ T cell counts despite high viremia for many years (viremic non progre...
ORGANISM(S): Homo sapiens 
2011-06-03 | E-GEOD-28128 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of rhesus macaques vaccinated with ALVAC-SIVgpe DNA + SIVgp120 protein subunit and unvaccinated controls after challenge with SIVmac251 - 3 wks post-infection
The SIVmac251 macaque model has been used to evaluate the efficacy of vaccine for HIV. Exposure of macaques to a single high dose of SIVmac251 results in transmission of multiple viral variants, which contrasts the few HIV variants typically transmitted in humans. In here, we investigated whether th...
ORGANISM(S): Macaca mulatta 
2013-03-01 | E-GEOD-37311 | biostudies-arrayexpress
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