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MetabolomicsMetabolic Phenotyping and Strain Characterisation of Pseudomonas aeruginosa Isolates from Cystic Fibrosis Patients Using Rapid Evaporative Ionisation Mass Spectrometry
Rapid evaporative ionisation mass spectrometry (REIMS) is a novel technique for the real-time analysis of biological material. It works by conducting an electrical current through a sample, causing it to rapidly heat and evaporate, with the analyte containing vapour channelled to a mass spectrometer...
2022-01-26 | MTBLS644 | MetaboLights
TranscriptomicsVariation in chromatin accessibility in human kidney cancer links H3K36 methyltransferase loss with widespread RNA processing defects
Comprehensive sequencing of human cancers has identified recurrent mutations in genes encoding chromatin regulatory proteins. For clear cell renal cell carcinoma (ccRCC), three of the five commonly mutated genes encode the chromatin regulators PBRM1, SETD2, and BAP1. How these mutations alter the ch...
ORGANISM(S): Homo sapiens 
2013-10-17 | E-MTAB-1936 | biostudies-arrayexpress
TranscriptomicsAn RNASeq normal tissue atlas for mouse and rat
The function of a gene is closely connected to its expression specificity across tissues and cell types. RNA-Seq is a powerful quantitative tool to explore genome wide expression. The aim of the present study is to provide a comprehensive RNA-Seq dataset across the same 13 tissues for mouse and rat,...
ORGANISM(S): Rattus norvegicus 
2017-10-25 | E-MTAB-6081 | biostudies-arrayexpress
UnknownRandomized international phase III trial of ERCC1 and RRM1 expression-based chemotherapy versus gemcitabine/carboplatin in advanced non-small-cell lung cancer.
Not available
S-EPMC3691357 | biostudies-literature
UnknownCPEB3 inhibits translation of mRNA targets by localizing them to P bodies.
Not available
S-EPMC6731686 | biostudies-literature
TranscriptomicsTransgenerational profiling of small non-coding RNAs in C.elegans RSD mutants
Attempt to identify progressive changes in small non-coding RNA levels in C.elegans lacking RSD-2 or RSD-6. Small non-coding RNA (18-30nt) was extracted from animals the indicated number of generations after homozygosity was established
ORGANISM(S): Caenorhabditis elegans 
2013-06-01 | E-GEOD-40457 | biostudies-arrayexpress
TranscriptomicsTransgenerational changes in small RNA profiles of C.elegans mutants lacking PRG-1
An attempt to identify small non-coding RNAs that change with increasing generations after becoming homozygous for the loss of PRG-1 Small non-coding RNA (18-30nt) was extracted from animals the indicated number of generations after homozygosity was established
ORGANISM(S): Caenorhabditis elegans 
2013-06-01 | E-GEOD-40572 | biostudies-arrayexpress
TranscriptomicsTranscriptomic and proteomic analyses of seasonal photoperiodism in the pea aphid
Aphid adaptation to harsh winter conditions is illustrated by an alternation of their reproductive mode. Aphids detect photoperiod shortening by sensing the length of the night and switch from viviparous parthenogenesis in spring and summer, to oviparous sexual reproduction in autumn. The photoperio...
ORGANISM(S): Acyrthosiphon pisum 
2010-06-19 | E-GEOD-15776 | biostudies-arrayexpress
TranscriptomicsDeep sequencing reveals abundant non-canonical onco-retroviral microRNAs in B-cell leukemia/lymphoma
Viral tumor models have significantly contributed to our understanding of oncogenic mechanisms. How transforming delta-retroviruses induce malignancy however remains poorly understood, especially as viral mRNA/protein are tightly silenced in tumors. Here, using deep sequencing of broad windows of sm...
ORGANISM(S): Ovis aries 
2013-01-24 | E-GEOD-42316 | biostudies-arrayexpress
TranscriptomicsHIF-2alpha Knockdown in A498 (VHL-/-) ccRCC cells
HIF-2alpha is essential for (VHL-/-) ccRCC subcutaneous tumor growth in mice, and in tumor cell lines, its inhibition results in increased ROS accumulation, tumor cell death and responsiveness to radiation treatment. We have utilized transcriptional profiling to screen for putative HIF-2alpha target...
ORGANISM(S): Homo sapiens 
2009-08-27 | E-GEOD-16622 | biostudies-arrayexpress
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