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Viruses manipulate cellular metabolism and macromolecule recycling processes like autophagy. Dysregulated metabolism might lead to excessive inflammatory and autoimmune responses as observed in severe and long COVID-19 patients. Here we show that SARS-CoV-2 modulates cellular metabolism and reduces ...
2021-06-11 | MTBLS2840 | MetaboLights
Genes involved in the autophagic pathway are risk factors for the development of inflammatory bowel disease. In addition, patients with Crohn’s disease exhibit a profound expansion of mesenteric fat during the pathology. We investigated in our study the role of autophagy in mature adipocyte during i...
ORGANISM(S): Mus musculus 
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease, characterized by synovial hyperplasia and progressive joint destruction. For treating inflammatory diseases, such as RA, the Janus kinase (JAK)-mediated signaling pathway has emerged as a therapeutic target. Therefore, JAK inhib...
ORGANISM(S): Mus musculus 
This is a reconstruction of the biochemical network of the yeast Saccharomyces cerevisiae carried out at a jamboree organized in April 2007 in the Manchester Centre for Integrative Systems Biology. It is the result of a consensus merger of two previous reconstr...
2005-01-01 | MODEL0072364382 | BioModels
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