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UnknownType III-A CRISPR-Cas Csm Complexes: Assembly, Periodic RNA Cleavage, DNase Activity Regulation, and Autoimmunity.
Not available
S-EPMC6355164 | biostudies-literature
TranscriptomicsFGF-dependent regulation of VEGF signaling via transcriptional control of VEGF receptor 2 expression
Numerous studies have suggested a link between fibroblast growth factor (FGF) and vascular endothelial growth factor (VEGF) signaling pathways; however the nature of this link has not been established. To evaluate this relationship we investigated VEGF signaling in endothelial cells with disrupted F...
ORGANISM(S): Mus musculus 
2011-06-07 | E-GEOD-28483 | biostudies-arrayexpress
TranscriptomicsSmall RNA survey of mouse genome
Using criteria based on known examples, we identified approximately 1.7 million and 2.4 million sequences encoding putative miRNA precursor (stem-loop) structures in the mouse and human genomes, respectively, as well as large numbers of such structures in the genomes of fish, fruitfly and nematode w...
ORGANISM(S): Mus musculus 
2010-05-18 | E-GEOD-7217 | biostudies-arrayexpress
UnknownAllosteric regulation in CRISPR/Cas1-Cas2 protospacer acquisition mediated by DNA and Cas2.
Not available
S-EPMC8390960 | biostudies-literature
TranscriptomicsEstrogen-dependent gene expression in human breast cancer cells relies upon proteosome-dependent monoubiquitination of histone H2B
The estrogen receptor-alpha (ERα) determines breast cancer cell phenotype and is a prognostic indicator. A better understanding of the mechanisms controlling ERα function may uncover improved strategies for the treatment of breast cancer. Proteasome inhibition was previously reported to regulate e...
ORGANISM(S): Homo sapiens 
2011-11-22 | E-GEOD-31118 | biostudies-arrayexpress
UnknownPAM binding ensures orientational integration during Cas4-Cas1-Cas2-mediated CRISPR adaptation.
Not available
S-EPMC9675710 | biostudies-literature
TranscriptomicsProteasome inhibition blocks estrogen-dependent gene transcription by decreasing histone H2B monoubiquitination in human breast cancer cells
The estrogen receptor-alpha (ERα) determines breast cancer cell phenotype and is a prognostic indicator. A better understanding of the mechanisms controlling ERα function may uncover improved strategies for the treatment of breast cancer. Proteasome inhibition was previously reported to regulate est...
ORGANISM(S): Homo sapiens 
2011-11-22 | E-GEOD-30931 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human coronary arteries from patients with and without collateral artery vessels to identify novel markers of coronary collateralization
Evaluation of transcriptional regulation in Coronary artery disease patients with and without collateral artery vessels.
ORGANISM(S): Homo sapiens 
2006-03-10 | E-MEXP-564 | biostudies-arrayexpress
UnknownCRISPR RNA-guided integrases for high-efficiency, multiplexed bacterial genome engineering.
Not available
S-EPMC10583764 | biostudies-literature
TranscriptomicsTranscription profiling by array of mouse ovary development to compare the expression of mRNAs and noncoding RNAs
This experiment compared the expression of mRNAs and noncoding RNAs during the development of mouse ovary. The primary aim of the experiment was to identify ncRNAs that were differentially expressed during this process.
ORGANISM(S): Mus musculus 
2010-05-12 | E-TABM-986 | biostudies-arrayexpress
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