Micro-array experiment was performed on URECs (Urine-derived Renal Epithelial Cells) from a patient carrying recessive NPHP1 mutation. URECs were treated either with 0.04% of DMSO or 2µM of Alprostadil for 24h.
Bulk RNAseq of kidneys from 5 months-old mice invalidated for Nphp1, which is the main gene responsible for Nephronophtisis, after 4 months of treatment with daily intraperitoneal injection of vehicle of Alprostadil (80µg/kg).
