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TranscriptomicsComparative analysis of Papaver somniferum genotypes having contrasting latex and alkaloid profiles
Sampada and Sujata are two contrasting genotypes of Papaver somniferum that are contrasting in terms of their latex and alkaloid profiles. The major objective of the present study was to use a small-scale (750 target genes) microarray of P. somniferum for identification of genes that are differentia...
ORGANISM(S): Papaver somniferum 
2013-12-30 | E-GEOD-37983 | biostudies-arrayexpress
TranscriptomicsA gene expression signature associated with K-Ras addiction reveals regulators of EMT and tumor cell survival
K-Ras mutations occur frequently in epithelial cancers. Using shRNAs to deplete K-Ras in lung and pancreatic cancer cell lines harboring K-Ras mutations, two classes were identified—lines that do or do not require K-Ras to maintain viability. Comparing these two classes of cancer cells revealed a g...
ORGANISM(S): Homo sapiens 
2009-03-06 | E-GEOD-15126 | biostudies-arrayexpress
TranscriptomicsEffect of P. gingivalis on human primary gingival epithelial cells
EXPERIMENT: Microarray expression profiles derived from the human primary gingival epithelial cells 24.0h after exposure to heat inactivated P. gingivalis ANIMAL MODEL: NON EXPOSURE: Human primary gingival epithelial cells (at 3rd passage) were exposed to heat inactivated P. gingivalis (MOI:100) at ...
ORGANISM(S): Homo sapiens 
2010-05-16 | E-GEOD-13042 | biostudies-arrayexpress
TranscriptomicsOral tongue cancer gene expression profiling: Identification of novel potential prognosticators
Background: The present study is aimed at identifying potential candidate genes as prognostic markers in human oral tongue squamous cell carcinoma (SCC) by large scale gene expression profiling. Methods: The gene expression profile of patients (n=37) with oral tongue SCC were analyzed using Affyme...
ORGANISM(S): Homo sapiens 
2008-11-14 | E-GEOD-13601 | biostudies-arrayexpress
TranscriptomicsA specific miRNA signature correlates with complete pathological response to neoadjuvant chemo-radiotherapy in locally advanced rectal cancer
Background: MicroRNAs (miRNAs) are small, non-coding, RNA molecules which regulate numerous cellular processes. Specific miRNA may be abnormally down-regulated or up-regulated in colorectal cancer and have been found associated with prognosis or response to treatments. However, no study has ever ad...
ORGANISM(S): Homo sapiens 
2012-04-24 | E-GEOD-29298 | biostudies-arrayexpress
TranscriptomicsExpression data from ethanol and saline exposed mice [mRNA]
Mouse models of Fetal Alcohol Spectrum Disorder can be used to assess molecular changes underlying the disorder. Neonatal ethanol exposure in mice can be used to model third trimester ethanol exposure in humans. Mice were injected with 2.5 g/kg twice on each of postnatal days 4 and 7. Mice were allo...
ORGANISM(S): Mus musculus 
2015-03-07 | E-GEOD-66644 | biostudies-arrayexpress
TranscriptomicsaCGH: Human SUM149-Luc triple-negative Inflammatory Breast Cancer cell line versus its metabolically adaptable variants MA1 and MA2
CGH array of MA1 and MA2 variant cells as compared to the parental SUM149-Luc breast cancer cell line. The MA1 and MA2 variants were isolated based on the ability of rare cancer cells to survive and grow without adding glutamine in culture medium. To gain insight into the characteristic of metabolic...
ORGANISM(S): Homo sapiens 
2014-10-03 | E-GEOD-60015 | biostudies-arrayexpress
TranscriptomicsTranscript profiling of the pea shoot apical meristem highlights processes underlying its function and maintenance
Plant growth is the result of cell proliferation in the meristems, which requires a dynamic balance between the formation of new tissue and the maintenance of a set of undifferentiated stem cells. There is much that remains unknown about this vital developmental process. In this study, we have repor...
ORGANISM(S): Pisum sativum 
2010-05-19 | E-GEOD-9278 | biostudies-arrayexpress
UnknownMutually inhibitory Ras-PI(3,4)P2 feedback loops mediate cell migration.
Not available
S-EPMC6166812 | biostudies-literature
TranscriptomicsFetal malformations and early embryonic gene expression response in Cynomolgus monkeys maternally exposed to thalidomide
EXPERIMENT: The animal experiments were performed at Shin Nippon Biomedical Laboratories (SNBL), Ltd. (Kagoshima, Japan) in compliance with the Guideline for Animal Experimentation (1987), and in accordance with the Law Concerning the Protection and Control of Animals (1973) and the Standards Relati...
ORGANISM(S): Macaca fascicularis 
2010-06-20 | E-GEOD-15542 | biostudies-arrayexpress
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