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MetabolomicsRNA-Seq and UHPLC-Q-TOF/MS Based Lipidomics Study in Lysiphlebia japonica
Lipids play an important role in energy storage, membrane structure stabilization and signaling. Parasitoids are excellent models to study lipidomics because a majority of them do not accumulate during their free-living life-stage. Studies on parasitoids have mostly focused on the changes in the lip...
2021-10-06 | MTBLS409 | MetaboLights
MetabolomicsIn-depth organic mass cytometry reveals differential contents of 3-hydroxybutanoic acid at the single-cell level
Comprehensive single-cell metabolic profiling is critical for revealing phenotypic heterogeneity and elucidating the molecular mechanisms underlying biological processes. However, single-cell metabolomics remains challenging because of the limited metabolite coverage and inability to discriminate is...
2026-08-14 | MTBLS8113 | MetaboLights
MetabolomicsLipidomics and RNA-Seq Study of Lipid Regulation in Aphis gossypii parasitized by Lysiphlebia japonica
The cotton-melon aphid, Aphis gossypii Glover, is a major insect pest worldwide. Lysiphlebia japonica (Ashmead) is an obligate parasitic wasp of A. gossypii, and has the ability to regulate lipid metabolism of the cotton-melon aphid. Lipids are known to play critical roles in energy homeostasis, mem...
2018-03-07 | MTBLS410 | MetaboLights
MetabolomicsIntegrative of Single-Cell RNA Sequencing and Metabolomics Decipher the Imbalanced Lipid-Metabolism in Maladaptive Immune Responses during Sepsis
To identify differentially expressed lipid metabolism-related genes (DE-LMRGs) responsible for immune dysfunction in sepsis. Machine learning algorithms were applied for screening hubgenes related to lipid metabolism. CIBERSORT and Single-sample GSEA were employed for assessing the immune cell infil...
2024-09-26 | MTBLS7315 | MetaboLights
MetabolomicsSingle-Cell and Spatial Multi-Omics Reveal Mechanical Stress Driving Heterogeneous Xylem Development in Populus [Spatial metabolomics_LCM]
Xylem, the predominant tissue for structural support, forms tension wood with G-layer-rich fibers under mechanical stress. Despite being recognized over a century ago, three key biological questions remained unclear: (1) Are fibers in normal and tension wood distinct cells due to morphological diffe...
2025-06-16 | MTBLS12561 | MetaboLights
MetabolomicsSingle-Cell and Spatial Multi-Omics Reveal Mechanical Stress Driving Heterogeneous Xylem Development in Populus [Spatial metabolomics_MALDI imaging]
Xylem, the predominant tissue for structural support, forms tension wood with G-layer-rich fibers under mechanical stress. Despite being recognized over a century ago, three key biological questions remained unclear: (1) Are fibers in normal and tension wood distinct cells due to morphological diffe...
2025-06-16 | MTBLS12601 | MetaboLights
MetabolomicsSingle-cell Transcriptomics and Time-series Metabolite Profiling Reveal the Spatiotemporal Regulation of Flavonoid Biosynthesis Genes and Phytohormone Homeostasis by PAP1 in Arabidopsis
Understanding the spatiotemporal regulation of specialized metabolism in plants is critical for advancing both basic plant biology and biotechnological applications. In this study, we utilized single-cell RNA sequencing (scRNA-seq) and time-series metabolite profiling to investigate the regulation o...
2025-05-27 | MTBLS12459 | MetaboLights
TranscriptomicsMassively parallel single-cell RNA-Seq for dissecting cell type and cell state compositions
In multi-cellular organisms, biological function emerges when cells of heterogeneous types and states are combined into complex tissues. Nevertheless unbiased dissection of tissues into coherent cell subpopulations is currently lacking. We introduce an automated, massively parallel single cell RNA s...
ORGANISM(S): Mus musculus 
2014-02-14 | E-GEOD-54006 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA-seq of primary human glioblastomas
We report transcriptomes from 430 single glioblastoma cells isolated from 5 individual tumors and 102 single cells from gliomasphere cells lines generated using SMART-seq. In addition, we report population RNA-seq from the five tumors as well as RNA-seq from cell lines derived from 3 tumors (MGH26, ...
ORGANISM(S): Homo sapiens 
2014-06-12 | E-GEOD-57872 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-seq for pGL2 and QC cells from the Arabidopsis thaliana root
To demonstrate our method of controlling for technical noise in single-cell RNA-seq experiments we manually collected single A. thaliana cells marked by the expression of green fluorescent protein (GFP) driven by either the GL2 or WOX5 promoters. Seven and six cells were collected from each cell typ...
ORGANISM(S): Arabidopsis thaliana 
2013-03-21 | E-MTAB-1499 | biostudies-arrayexpress
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