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UnknownEffects of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan on disability and cognitive function after recurrent stroke in patients with ischaemic stroke in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial: a double-blind, active and placebo-controlled study.

Background

The treatment of ischaemic stroke with neuroprotective drugs has been unsuccessful, and whether these compounds can be used to reduce disability after recurrent stroke is unknown. The putative neuroprotective effects of antiplatelet compounds and the angiotensin II receptor antago...
S-EPMC2772657 | biostudies-literature
UnknownTelmisartan to prevent recurrent stroke and cardiovascular events.

Background

Prolonged lowering of blood pressure after a stroke reduces the risk of recurrent stroke. In addition, inhibition of the renin-angiotensin system in high-risk patients reduces the rate of subsequent cardiovascular events, including stroke. However, the effect of lowering of blood ...
S-EPMC2714258 | biostudies-literature
UnknownAspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke.

Background

Recurrent stroke is a frequent, disabling event after ischemic stroke. This study compared the efficacy and safety of two antiplatelet regimens--aspirin plus extended-release dipyridamole (ASA-ERDP) versus clopidogrel.

Methods

In this double-blind, 2-by-2 factorial trial, w...
S-EPMC2714259 | biostudies-literature
UnknownEffect of Lung Recruitment and Titrated Positive End-Expiratory Pressure (PEEP) vs Low PEEP on Mortality in Patients With Acute Respiratory Distress Syndrome: A Randomized Clinical Trial.

Importance

The effects of recruitment maneuvers and positive end-expiratory pressure (PEEP) titration on clinical outcomes in patients with acute respiratory distress syndrome (ARDS) remain uncertain.

Objective

To determine if lung recruitment associated with PEEP titration according ...
S-EPMC5710484 | biostudies-literature
UnknownInternational Impact of COVID-19 on the Diagnosis of Heart Disease.

Background

The coronavirus disease 2019 (COVID-19) pandemic has adversely affected diagnosis and treatment of noncommunicable diseases. Its effects on delivery of diagnostic care for cardiovascular disease, which remains the leading cause of death worldwide, have not been quantified.

Obje...

S-EPMC7836433 | biostudies-literature
UnknownImpact of COVID-19 on Cardiovascular Testing in the United States Versus the Rest of the World.

Objectives

This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-U.S. institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic.

Background

The COVID-19 pandemic has disrupted the c...
S-EPMC8374310 | biostudies-literature
UnknownImpact of COVID-19 Pandemic on Cardiovascular Testing in Asia: The IAEA INCAPS-COVID Study.

Background

The coronavirus disease-2019 (COVID-19) pandemic significantly affected management of cardiovascular disease around the world. The effect of the pandemic on volume of cardiovascular diagnostic procedures is not known.

Objectives

This study sought to evaluate the effects of ...
S-EPMC9627847 | biostudies-literature
UnknownWorldwide Disparities in Recovery of Cardiac Testing 1 Year Into COVID-19.

Background

The extent to which health care systems have adapted to the COVID-19 pandemic to provide necessary cardiac diagnostic services is unknown.

Objectives

The aim of this study was to determine the impact of the pandemic on cardiac testing practices, volumes and types of diagnos...
S-EPMC9109706 | biostudies-literature
UnknownAI is a viable alternative to high throughput screening: a 318-target study.
High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand chemical libraries can access far greater chemical space, provided that...
S-EPMC10987645 | biostudies-literature
UnknownA cluster randomized trial of a multifaceted quality improvement intervention in Brazilian intensive care units: study protocol.

Background

The uptake of evidence-based therapies in the intensive care environment is suboptimal, particularly in limited-resource countries. Checklists, daily goal assessments, and clinician prompts may improve compliance with best practice processes of care and, in turn, improve clinical ...
S-EPMC4342101 | biostudies-literature
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