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TranscriptomicssiRNA profiling of HeLa cells reveals strand-specific 5-O-methylation of siRNA duplexes controls guide strand selection and targeting specificity.
Small interfering RNAs (siRNAs) and microRNAs (miRNAs) guide catalytic sequence-specific cleavage of fully or nearly fully complementary target mRNAs or control translation and/or stability of many mRNAs that share 6-8 nucleotides (nt) of complementarity to the siRNA and miRNA 5' end. siRNA- and miR...
ORGANISM(S): Homo sapiens 
2008-06-11 | E-GEOD-10960 | biostudies-arrayexpress
Transcriptomicshuman hTERT-RPE1 cell spheroid : Control siRNA transfected vs. YAP1 siRNA transfected
Transcriptional profiling of human hTERT-RPE1 cell spheroids comparing Control siRNA transfected hTERT-RPE1 cell spheroids with those transfected with YAP1 siRNA. Two-condition experiment, Control siRNA vs.YAP1 siRNA hTERT-RPE1 cell spheroids. Biological replicates: 1 Control siRNA, 1YAP1 siRNA tran...
ORGANISM(S): Homo sapiens 
2015-02-01 | E-GEOD-54146 | biostudies-arrayexpress
TranscriptomicsGene profile in H1299 cells treated with PTD-DRBD GAPDH siRNA or treated with Lipofection GAPDH siRNA
Whole genome microarrays were probed with total mRNA from PTD-DRBD GAPDH siRNA treated H1299 cells at 12 h and 24 h. Using a 1.6x fold increase/decrease filter of cellular mRNAs, we detected a dramatic reduction in the target GAPDH mRNA along with a limited number of both up and down regulated genes...
ORGANISM(S): Homo sapiens 
2010-05-08 | E-GEOD-15723 | biostudies-arrayexpress
TranscriptomicssiRNA profiling of human cells knocked down for optineurin
This study aimed to identify genes that are linked with optineurin expression using a combined siRNA-microarray approach Experiment Overall Design: Samples a01, a02 and a03 were treated with siRNA specific for optineurin mRNA Experiment Overall Design: Samples b01, b02 and b03 were treated with wate...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-6819 | biostudies-arrayexpress
TranscriptomicsProbing the off-target effect of EGFP siRNA and pro-siRNA in the HeLa-d1EGFP cell line
We have develped a novel method of making siRNAs (named pro-siRNA for prokaryotic siRNA). To evaluate off-targeting of pro-siRNA, we compared the mRNA expression profiles of HeLa-d1EGFP cells transfected with 4 nM EGFP siRNAs and pro-siRNAs by microarray. We used microarray to study the off-target e...
ORGANISM(S): Homo sapiens 
2013-02-12 | E-GEOD-44256 | biostudies-arrayexpress
TranscriptomicsAnalysis of global gene expression profiles of A549 cells treated with SETX siRNA upon Influenza A/PR/8/34(ΔNS1) Infection
Untransfected (no siRNA), control siRNA or SETX siRNA treated A549 cells were infected with A/Puerto Rico/8/1934(ΔNS1) for 4 hours 3 Biological Replicates per condition
ORGANISM(S): Homo sapiens 
2015-03-30 | E-GEOD-52932 | biostudies-arrayexpress
TranscriptomicsLymph node stromal cells: Control siRNA treated vs. Eif4g3 siRNA treated
Gene expression in the top, light and heavy polysome fractions of Eif4g3 siRNA treated lymph node stromal cells (LNSCs) compared to control-sIRNA treated samples This study was performed to examine whether the expression of certain genes in LNSCs is regulated by the translation factor, eukaryotic tr...
ORGANISM(S): Mus musculus 
2011-08-31 | E-GEOD-29152 | biostudies-arrayexpress
TranscriptomicsAnalysis of global gene expression profiles of A549 cells treated with Xrn2 siRNA upon Influenza A/PR/8/34(ΔNS1) Infection
Untransfected (no siRNA), control siRNA or Xrn2 siRNA treated A549 cells were infected with A/Puerto Rico/8/1934(ΔNS1) for 4 hours 3 Biological Replicates per condition
ORGANISM(S): Homo sapiens 
2015-03-30 | E-GEOD-66661 | biostudies-arrayexpress
TranscriptomicssiRNA profiling of human primary prostate stromal cells knocked down for FOXF2
To identify the genes and pathways regulated by FOXF2, we investigated potential FOXF2 gene targets by microarray analyses of primary prostate stromal cells (PrSC) in which FOXF2 was knocked down by siRNA. 190 differentially expressed genes were selected, of which 104 genes were more highly expresse...
ORGANISM(S): Homo sapiens 
2008-11-13 | E-GEOD-12444 | biostudies-arrayexpress
TranscriptomicssiRNA-mediated HNRPA2B1 knock-down in MDA-MB-231 cells
Transcriptional profiling of MDA-MB-231 comparing the siRNA-mediated HNRPA2B1 knock-downs versus mock-transfected controls Three siRNA vs mock transfections
ORGANISM(S): Homo sapiens 
2012-02-28 | E-GEOD-35757 | biostudies-arrayexpress
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