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MetabolomicsA metabolomic study of adipose tissue in mice with a disruption of the circadian system

Adipose tissue functions in terms of energy homeostasis as a rheostat for blood triglyceride, regulating its concentration, in response to external stimuli. In addition it acts as a barometer to inform the central nervous system of energy levels which can vary dramatically between meals and accor...

2017-10-27 | MTBLS382 | MetaboLights
TranscriptomicsStructural basis for retroviral integration into nucleosomes
Retroviral integration is catalyzed by a tetramer of integrase (IN) assembled on viral DNA ends in a stable complex, known as the intasome. How the intasome interfaces with chromosomal DNA, which exists in the form of nucleosomal arrays, is currently unknown. Here we show that the prototype foamy vi...
ORGANISM(S): Homo sapiens 
2015-06-10 | E-GEOD-67730 | biostudies-arrayexpress
UnknownA system for site-specific integration of transgenes in mammalian cells.
Not available
S-EPMC6657834 | biostudies-literature
UnknownA Novel Site-Specific Integration System for Genetic Modification of Aspergillus flavus.
Not available
S-EPMC7003095 | biostudies-literature
GenomicsSite-Specific HPV18 Integration Facilitates Cervical Carcinogenesis through metabolic reprogramming-Induced dysfunction of the SpHK1/S1P/S1PR1 pathway
Site-Specific HPV18 Integration Facilitates Cervical Carcinogenesis through metabolic reprogramming-Induced dysfunction of the SpHK1/S1P/S1PR1 pathway
PRJNA1205690 | ENA
TranscriptomicsGenome position and gene amplification - expressional profiling of methotrexate resistant colonies
We investigated the influence of genome position on propensity to amplify. First, we integrated a mutant form of DHFR into different positions in the human genome, challenged cells with methotrexate and then studied the genomic alterations arising in drug resistant cells. We observed site specific d...
ORGANISM(S): Homo sapiens 
2007-10-08 | E-GEOD-6361 | biostudies-arrayexpress
UnknownHigh efficiency Agrobacterium-mediated site-specific gene integration in maize utilizing the FLP-FRT recombination system.
Not available
S-EPMC6662307 | biostudies-literature
GenomicsSite-Specific HPV18 Integration Facilitates Cervical Carcinogenesis through metabolic reprogramming-Induced dysfunction of the SpHK1/S1P/S1PR1 pathway-part2
Site-Specific HPV18 Integration Facilitates Cervical Carcinogenesis through metabolic reprogramming-Induced dysfunction of the SpHK1/S1P/S1PR1 pathway-part2
PRJNA1206104 | ENA
ProteomicsDevelopment of an in vitro screening system for synthetic signal peptide in mammalian cell-based protein production.
Optimizing appropriate signal peptides in mammalian cell-based protein production is crucial given that most recombinant proteins produced in mammalian cells are thought to be secreted proteins. Until now, most studies on signal peptide in mammalian cells have replaced native signal peptides with we...
ORGANISM(S): Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 
2022-05-24 | PXD033441 | Pride
N-terminal sequencing using lc-ms/ms Site-specific integration system Fc-fusion protein production Signal peptide Mammalian cells Screening system 
GenomicsThe PhoP-dependent ncRNA Mcr7 modulates the TAT secretion system in Mycobacterium tuberculosis [ChIP-Seq]
The PhoPR two-component system is essential for virulence in Mycobacterium tuberculosis where it controls expression of approximately 2% of the genes, including those for the ESX-1 secretion apparatus, a major virulence determinant. Mutations in phoP lead to compromised production of pathogen-specif...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2014-06-02 | E-GEOD-54239 | biostudies-arrayexpress
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