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ModelsSivakumar2011 - Notch Signaling Pathway
Sivakumar2011 - Notch Signaling Pathway Notch is a transmembrane receptor that mediates local cell-cell communication and coordinates a signaling cascade. It plays a key role in modulating cell fate decisions throughout the development of invertebrate and vertebrate species and the misregulati...
2024-09-02 | BIOMD0000000396 | BioModels
ModelsSivakumar2011 - EGF Receptor Signaling Pathway
Sivakumar2011 - EGF Receptor Signaling Pathway EGFR belongs to the human epidermal receptor (HER) family of receptor tyrosine kinases, which consists of four closely related receptors (EGFR (HER1, erbB1), HER2 (neu, erbB2), HER3 (erbB3), and HER4 (erbB4)) that mediate cellular signaling pathwa...
2024-09-02 | BIOMD0000000394 | BioModels
ModelsSivakumar2011 - Hedgehog Signaling Pathway
Sivakumar2011 - Hedgehog Signaling Pathway This is the current model for the Hedgehog signaling pathway. The best data for mechanism of signaling has been worked out in Drosophila, so this model is based largely on Drosophila data. Hedgehog target genes vary from tissue to tissue, so the ident...
2024-09-02 | BIOMD0000000395 | BioModels
ModelsSivakumar2011_WntSignalingPathway
Sivakumar2011_WntSignalingPathway The secreted protein Wnt activates the heptahelical receptor Frizzled on nieghboring cells. Activation of Frizzled causes the recruitment of additional membrane proteins which in turn result in 1) the activation of the protein Dishevelled via phosphorylation and 2) ...
2024-09-02 | BIOMD0000000397 | BioModels
ModelsSivakumar2011_NeuralStemCellDifferentiation_Crosstalk
Sivakumar2011_NeuralStemCellDifferentiation_Crosstalk This model is generated by integrating BIOMD0000000394 (EGFR), BIOMD0000000395 (Hedgehog), BIOMD0000000396 (Notch) and BIOMD0000000397 (Wnt), to investigate the signalling crosstalk between the four pathways. This model is described in th...
2024-09-02 | BIOMD0000000398 | BioModels
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