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TranscriptomicsLayer 4 Visual Cortex Star Pyramid Monocular Deprivation Microarray Study
Microarray expression profiling of manually sorted m-citirin-labeled layer 4 visual cortex star pyramid neurons from deprived and non-deprived hemispheres. Monocular deprivation by TTX-injection (at P12-13 and again at P13-14), followed by manual sorting of m-Citrin-labeled Layer 4 Visual Cortex Sta...
ORGANISM(S): Mus musculus 
2014-04-12 | E-GEOD-56758 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse B cells from wild type or mir-155 deficient mice, treated with a-mir155 PNA
B cells were extracted from spleens of mice treated with PNA a-miR155 and vehicle treated mice either wild type or mir-155 deficient. All mice received LPS to induce mir155 expression.
ORGANISM(S): Mus musculus 
2010-03-24 | E-MEXP-2587 | biostudies-arrayexpress
TranscriptomicsExpression data from skeletal muscle satellite cells at different development stages
Satellite cells are responsible for the long-term regenerative capacity of adult skeletal muscle. The diminished muscle performance and regenerative capacity of aged muscle is thought to reflect progressive fibrosis and atrophy. Whether this reduction in muscle competency also involves a diminishmen...
ORGANISM(S): Mus musculus 
2014-05-26 | E-GEOD-47401 | biostudies-arrayexpress
TranscriptomicsExpression profiling of wildtype mouse cornea in development, adult, and aging
While the mouse cornea has been well characterized morphologically, the transcriptional changes have not been described in detail. To characterize the genes, pathways, and transcriptional regulators involved in mouse cornea development and aging, we isolated whole cornea from wildtype CB6 mice at se...
ORGANISM(S): Mus musculus 
2013-01-01 | E-GEOD-43155 | biostudies-arrayexpress
TranscriptomicsMulti-level omics analysis of gene expression in a murine model of dystrophin loss and therapeutic restoration [mRNA]
Duchenne muscular dystrophy (DMD) is a classical monogenic disorder, a model disease for genomic studies and a priority candidate for regenerative medicine and gene therapy. Although the genetic cause of DMD is well known, the molecular pathogenesis of disease and the response to therapy are incompl...
ORGANISM(S): Mus musculus 
2015-09-24 | E-GEOD-64418 | biostudies-arrayexpress
TranscriptomicsLiver adapts mitochondrial function to insulin-resistant and diabetic states in mice
Objective: To study if diabetic and insulin-resistant states lead to mitochondrial dysfunction in the liver, or alternatively, if there is adaption of mitochondrial function to these states in the long-term range. Results: High-fat diet (HFD) caused insulin resistance and severe hepatic lipid accum...
ORGANISM(S): Mus musculus 
2013-12-10 | E-GEOD-39752 | biostudies-arrayexpress
TranscriptomicsExpression data of influenza A-infected human type I-like alveolar epithelial cells
Pandemic influenza H1N1 (pdmH1N1) virus causes mild disease in humans but occasionally leads to severe complications and even death, especially in those who are pregnant or have underlying disease. Cytokine responses induced by pdmH1N1 viruses in vitro are comparable to other seasonal influenza viru...
ORGANISM(S): Homo sapiens 
2010-10-06 | E-GEOD-24533 | biostudies-arrayexpress
TranscriptomicsGenomics of medulloblastoma identifies four distinct molecular variants
Recent genomic approaches have suggested the existence of multiple distinct subtypes of medulloblastoma. We studied a large cohort of medulloblastomas to determine how many subgroups of the disease exist, how they differ, and the extent of overlap between subgroups. We determined gene expression p...
ORGANISM(S): Homo sapiens 
2010-09-13 | E-GEOD-21140 | biostudies-arrayexpress
TranscriptomicsExpression profiling across mouse epithelial tissues
To characterize genes, pathways, and transcriptional regulators enriched in the mouse cornea, we compared the expression profiles of whole mouse cornea, bladder, esophagus, lung, proximal small intestine, skin, stomach, and trachea. Total RNA was purified from esophagus, lung, proximal small intesti...
ORGANISM(S): Mus musculus 
2013-01-15 | E-GEOD-43381 | biostudies-arrayexpress
TranscriptomicsGene Expression in Transformed Lymphocytes Reveals Phenotype-Modifying Pathways in Cystic Fibrosis
Heritable genetic variants modify cystic fibrosis (CF) clinical phenotypes, e.g., lung disease, age-of-onset of persistent Pseudomonas aeruginosa (P. aeruginosa), and meconium ileus (MI).  Previous genome wide association studies (GWAS) have begun to inform the genetic architecture of CF phenotypes...
ORGANISM(S): Homo sapiens 
2016-05-19 | E-GEOD-60690 | biostudies-arrayexpress
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