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ProteomicsMass spectrometry-based proteomic characterization of cutaneous melanoma ectosomes reveals the presence of cancer-related molecules
Cutaneous melanoma (CM) is an aggressive type of skin cancer for which effective biomarkers are still needed. Due to the development of protocols for their successful isolation, protein content of extracellular vesicles (EVs) (including ectosomes and exosomes) became increasingly investigated in ter...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-02-03 | MSV000084892 | MassIVE
ProteomicsMass spectrometry based identification of similarities and differences in protein content of cutaneous melanoma cell lines and exosomes
Intercellular transport of proteins mediated by extracellular vesicles (EVs) exosomes and ectosomes, is one of the factors facilitating carcinogenesis. Therefore, the research on protein cargo of melanoma-derived EVs may provide a better understanding of mechanisms related to melanoma progression an...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-12-15 | MSV000090907 | MassIVE
ProteomicsMelanopsin (OPN4) is a novel oncogene in cutaneous melanoma: evidence from an experimental study
The goal of this study was to evaluate the role of OPN4 in melanoma development using in vitro, in vivo, and proteomics approaches.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2021-12-17 | MSV000088579 | MassIVE
TranscriptomicsComparative genomic hybridization of 23 human nevi with a pool of primary cutaneous melanoma
Genomic profiles comparing 23 nevi with a pool of primary cutaneous melanoma
ORGANISM(S): Homo sapiens 
2009-04-16 | E-TABM-3 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human tissue samples to identify novel genes associated with malignant melanoma but not benign melanocytic lesions
A number of melanoma specific genes were identified to differentiate clinical relevant tissue samples containing benign from malignant melanocytes. Experiment Overall Design: 7 normal skin, 18 nevi and 45 melanoma samples
ORGANISM(S): Homo sapiens 
2007-09-06 | E-GEOD-3189 | biostudies-arrayexpress
TranscriptomicsGene expression in melanocytes and metastases melanoma cells from the pig
Melanoblastoma-bearing Libechov minipigs (MeLiM) provide an animal model for the study of spontaneous cutaneous melanoma. We compared the serial analysis of gene expression (SAGE) profile between normal skin melanocytes and melanoma cells from a pulmonary metastasis of MeLiM. Keywords: disease stat...
ORGANISM(S): Sus scrofa 
2008-05-07 | E-GEOD-5982 | biostudies-arrayexpress
TranscriptomicsAnalysis of whole-genome chromosomal alterations in primary cutaneous melanoma
In this experiment, FFPE samples of 41 primary cutaneous melanoma, 2 metastatic melanoma and 6 normal skin were used for DNA extraction and genotyping by Affymetrix OncoScan FFPE Assay, in order to define chromosomal alterations in copy number and loss of heterozygosity. Genomic damage was then cor...
ORGANISM(S): Homo sapiens 
2015-11-01 | E-MTAB-3481 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of cohort of human cutaneous primary melanomas associated with a distant metastasis free survival
Identification of genomic characteristics in a cohorte of human cutaneous primary melanoma associated with a distant metastasis free survival.
ORGANISM(S): Homo sapiens 
2007-04-01 | E-TABM-1 | biostudies-arrayexpress
TranscriptomicsAffymetrix expression array data for melanoma progression to the brain
Melanoma is one of the most aggressive and treatment-resistant cancers. It represents the most life-threatening neoplasm of the skin, and its incidence has been increasing for the last three decades. Melanoma evolves from the local transformation of melanocytes to primary tumors, which can metastasi...
ORGANISM(S): Homo sapiens 
2013-09-19 | E-GEOD-44660 | biostudies-arrayexpress
TranscriptomicsRNA-Seq whole transcriptome analysis of normal human epidermal keratinocytes and cutaneous squamous cell carcinoma cell lines.
The incidence of keratinocyte-derived skin cancer, cutaneous squamous cell carcinoma (cSCC) is increasing worldwide making it the second most common metastatic skin cancer. In this project we used SOLiD next generation sequencing to characterize gene expression profiles in normal human epidermal ker...
ORGANISM(S): Homo sapiens 
2015-08-27 | E-GEOD-66412 | biostudies-arrayexpress
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