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TranscriptomicsmiRNA expression profiling in squamous cell carcinoma (SCC)
Despite its prevalence, the molecular basis of squamous cell carcinoma (SCC) remains poorly understood. We recently identified the developmental transcription factor Grhl3 as a potent tumor suppressor of SCC, and demonstrated that targeting of Grhl3 by a miR-21-dependent proto-oncogenic network unde...
ORGANISM(S): Homo sapiens 
2013-01-18 | E-GEOD-32868 | biostudies-arrayexpress
ProteomicsSkin cancer-associated S. aureus downregulates DNA repair mechanisms, and promotes oxidative stress and DNA damage in human keratinocytes
Actinic keratoses (AK) are premalignant lesions common on photo-damaged skin that, over time, can progress to squamous cell carcinoma (SCC). A high bacterial load of Staphylococcus aureus is associated with AK and SCC but it is unknown whether this has a direct impact on skin cancer development. To ...
ORGANISM(S): Staphylococcus Capitis Staphylococcus Aureus Staphylococcus Epidermidis Staphylococcus 
2022-05-17 | PXD031676 | panorama
TranscriptomicsETS Family Transcriptional Regulators Drive Chromatin Dynamics and Malignancy in Squamous Cell Carcinomas (RNA-Seq I)
After characterizing super-enhancer-associated chromatin dynamics accompanied by malignant progression of skin stem cells, we show that ETS family members auto-regulate themselves and a cohort of cancer-associated super-enhancer transcription factors which together are essential for tumor maintenanc...
ORGANISM(S): Mus musculus 
2015-11-22 | E-GEOD-72146 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human skin lesions diagnosed as actinic keratosis, intraepidermal carcinoma or squamous cell carcinoma
We report whole tissue RNA-seq data captured from 25 AK, IEC or SCC lesions obtained from the skin of 17 individuals. We used RNA-seq to detect and measure HPV E7 transcription.
ORGANISM(S): Homo sapiens 
2018-07-09 | E-MTAB-6430 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human normal skin, actinic keratosis and squamous cell carcinoma
normal skin (no), actinic keratosis (ak), and squamous cell carcinoma (scc) of the skin were examined:; BACKGROUND: Carcinogenesis is a multi-step process indicated by several genes up- or down-regulated during tumor progression. This study examined and identified differentially expressed genes in c...
ORGANISM(S): Homo sapiens 
2007-10-02 | E-GEOD-2503 | biostudies-arrayexpress
TranscriptomicsKGF effects on cutaneous SCC cells
Keratinocyte growth factor (KGF, fibroblast growth factor-7) is a fibroblast-derived mitogen, which stimulates proliferation of epithelial cells. The expression of KGF by dermal fibroblasts is induced following injury and it promotes wound repair. However, the role of KGF in cutaneous carcinogenesis...
ORGANISM(S): Homo sapiens 
2012-05-01 | E-GEOD-34652 | biostudies-arrayexpress
UnknownAldo-keto reductase 1C3 is overexpressed in skin squamous cell carcinoma (SCC) and affects SCC growth via prostaglandin metabolism.
Not available
S-EPMC4125433 | biostudies-literature
GenomicsGene expression profile of cancer stem cells (CSCs) isolated from wild type (WT) and Sfrp1-/- mice skin squamous cell carcinoma (SCC)
Gene expression profile of cancer stem cells (CSCs) isolated from wild type (WT) and Sfrp1-/- mice skin squamous cell carcinoma (SCC)
PRJNA592542 | ENA
TranscriptomicsCancer stem cell features shift during skin squamous cell carcinoma progression
Cancer stem cells (CSCs) play a key role in tumour growth and metastasis. Although an expansion of CSC population was previously described in advanced cutaneous squamous cell carcinoma (SCC), it remains unknown whether CSC regulatory mechanisms also change through tumour progression to promote malig...
ORGANISM(S): Mus musculus 
2016-01-08 | E-GEOD-59439 | biostudies-arrayexpress
TranscriptomicsDefining an invasion signature at the leading edge of cutaneous squamous cell carcinoma (SCC): IL-24 driven MMP-7 and MMP-13 expression.
Purpose: Primary cutaneous squamous cell carcinoma (SCC) can be an invasive cancer in skin and has the potential to metastasize. We aimed to define the cancer related molecular changes that distinguish non-invasive from invasive SCC. Experimental design: We used laser capture microdissection techni...
ORGANISM(S): Homo sapiens 
2013-04-30 | E-GEOD-42677 | biostudies-arrayexpress
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