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TranscriptomicsNeurotrophin NT3 promotes ovarian primordial to primary follicle transition
Neurotrophins are growth factors that are known to have a role in promoting cell survival and differentiation. The focus of the current study is to examine the role of neurotrophins in regulating ovarian primordial follicle development. Ovaries from 4-day old rats were placed into organ culture and ...
ORGANISM(S): Rattus norvegicus 
2010-02-21 | E-GEOD-20358 | biostudies-arrayexpress
TranscriptomicsEnvironmentally induced epigenetic transgenerational inheritance of ovarian disease
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Rattus norvegicus 
2014-07-17 | E-GEOD-59278 | biostudies-arrayexpress
TranscriptomicsEnvironmentally Induced Epigenetic Transgenerational Inheritance of Altered Sertoli Cell Transcriptome and Epigenome: Molecular Etiology of Male Infertility
Environmental toxicants have been shown to induce the epigenetic transgenerational inheritance of adult onset disease, including testis disease and male infertility. The exposure of a gestating female during the period of gonadal sex determination has been shown to promote sperm epimutations, diffe...
ORGANISM(S): Rattus norvegicus 
2012-09-27 | E-GEOD-41173 | biostudies-arrayexpress
TranscriptomicsDioxin (TCDD) Induces Epigenetic Transgenerational Inheritance of Adult Onset Disease and Sperm Epimutations
Environmental compounds can promote epigenetic transgenerational inheritance of adult-onset disease in subsequent generations following ancestral exposure during fetal gonadal sex determination. The current study examined the ability of dioxin (2,3,7,8-tetrachlorodibenzo[p]dioxin, TCDD) to promote e...
ORGANISM(S): Rattus norvegicus 
2014-07-22 | E-GEOD-59552 | biostudies-arrayexpress
TranscriptomicsHydrocarbons (Jet Fuel JP-8) Induce Epigenetic Transgenerational Inheritance of Obesity, Reproductive Disease and Sperm Epimutations
Environmental compounds have been shown to promote epigenetic transgenerational inheritance of disease. The current study was designed to determine if a hydrocarbon mixture involving jet fuel (JP-8) promotes epigenetic transgenerational inheritance of disease. Gestating F0 generation female rats wer...
ORGANISM(S): Rattus norvegicus 
2014-07-22 | E-GEOD-59553 | biostudies-arrayexpress
TranscriptomicsPesticide and Insect Repellent Mixture (Permethrin and DEET) Induces Epigenetic Transgenerational Inheritance of Disease and Sperm Epimutations
Environmental compounds are known to promote epigenetic transgenerational inheritance of disease. The current study was designed to determine if a M-bM-^@M-^\pesticide mixtureM-bM-^@M-^] (pesticide permethrin and insect repellent N,N-Diethyl-meta-toluamide, DEET) promotes epigenetic transgenerationa...
ORGANISM(S): Rattus norvegicus 
2014-07-22 | E-GEOD-59554 | biostudies-arrayexpress
TranscriptomicsPlastics Derived Endocrine Disruptors (BPA, DEHP and DBP) Induce Epigenetic Transgenerational Inheritance of Obesity, Reproductive Disease and Sperm Epimutations
Environmental compounds are known to promote epigenetic transgenerational inheritance of adult onset disease in subsequent generations (F1M-bM-^@M-^SF3) following ancestral exposure during fetal gonadal sex determination. The current study was designed to determine if a mixture of plastic derived en...
ORGANISM(S): Rattus norvegicus 
2014-07-22 | E-GEOD-59555 | biostudies-arrayexpress
TranscriptomicsGene Bionetwork Analysis of Ovarian Primordial Follicle Development
Ovarian primordial follicles are critical for female reproduction and comprise a finite pool of gametes arrested in development. A systems biology approach was used to identify regulatory gene networks essential for primordial follicle development. Transcriptional responses to eight different growth...
ORGANISM(S): Rattus norvegicus 
2010-06-13 | E-GEOD-20324 | biostudies-arrayexpress
TranscriptomicsEnvironmentally Induced Epigenetic Transgenerational Inheritance of Altered Sertoli Cell Transcriptome and Epigenome: Molecular Etiology of Male Infertility
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Rattus norvegicus 
2014-07-07 | E-GEOD-59110 | biostudies-arrayexpress
TranscriptomicsEnvironmentally Induced Epigenetic Transgenerational Inheritance of Ovarian Disease [NimbleGen]
The actions of environmental toxicants and relevant mixtures in promoting the epigenetic transgenerational inheritance of ovarian disease was investigated with the use of a fungicide, a pesticide mixture, a plastic mixture, dioxin and a hydrocarbon mixture. After transient exposure of an F0 gestatin...
ORGANISM(S): Rattus norvegicus 
2014-07-17 | E-GEOD-59277 | biostudies-arrayexpress
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