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Adult skull bone marrow is an expanding and resilient hematopoietic reservoir
The aim of this study was to characterize in vivo miRNA expression in normal myeloid development of the neutrophil granulocyte (granulopoiesis) to gain insight into miRNA control of these processes. Cell populations highly enriched in precursors from successive stages of granulopoiesis and mature ne...
ORGANISM(S): Homo sapiens 
Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels
Lymphoid structures in the skull bone marrow control homeostatic and anti-tumor immune responses in the CNS [skull/sternum]
Lymphoid structures in the skull bone marrow control homeostatic and anti-tumor immune responses in the CNS [dura/skull/sternum]
We have previously shown that skull bone marrow derived myeloid cells are different from their blood derived counterparts. Whether or not cues from the CNS microenvironment differentially shape the skull bone marrow niche relative to peripheral bone marrow niches is unknown. To test this, we perform...
ORGANISM(S): Mus musculus 
2022-01-11 | GSE184766 | GEO
The bone marrow microenvironment is a critical regulator of hematopoietic stem cell self-renewal and fate. While it is appreciated that aging, chronic inflammation and other insults compromise bone marrow function and thereby negatively affect hematopoiesis, it is not known whether different bone co...
ORGANISM(S): Mus musculus 
2024-08-22 | GSE275179 | GEO
Lymphoid structures in the skull bone marrow control homeostatic and anti-tumor immune responses in the CNS [skull/brain]
Brain-Engrafted Monocyte-derived Macrophages from Blood and Skull-Bone Marrow Exhibit Distinct Properties [scRNA_FIRE-ctrl-blood-skull]
COVID-19 has been associated with a variety of neurological symptoms, including brain fog and brain tissue loss. This raises concerns about the virus's acute and potential chronic impacts on the brain. Using whole mouse and human tissue clearing, we determined all potential tissues targeted by the S...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2024-12-02 | PXD050384 | Pride
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