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MetabolomicsGain-of-function genetic screens in human cells identify SLC transporters overcoming environmental nutrient restrictions

Solute carrier (SLC) transporters control fluxes of nutrients and metabolites across membranes and thereby represent a critical interface between the microenvironment and cellular and subcellular metabolism. Because of substantial functional overlap, the interplay and relative contributions of SL...

2022-09-20 | MTBLS4268 | MetaboLights
MetabolomicsEpistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import
About a thousand genes in the human genome encode for membrane transporters. Among these, several solute carrier proteins (SLCs), representing the largest group of transporters, are still orphan and lack functional characterization. We reasoned that assessing genetic interactions among SLCs may be a...
2021-03-29 | MTBLS2205 | MetaboLights
MetabolomicsSeryl-leucine core 1 O-glycosylated peptide (SLC1G) identification
Not available
ORGANISM(S): Homo sapiens 
ST001104 | MetabolomicsWorkbench
MetabolomicsDeletion of the diabetes candidate gene Slc16a13 in mice
Not available
ORGANISM(S): Mus musculus 
ST001643 | MetabolomicsWorkbench
MetabolomicsEndothelial SLC25A13 links glutamine metabolism to angiogenesis
Attention to exploring endothelial cell (EC) metabolism is increasing, but a holistic perspective on the metabolic adaptations of ECs during angiogenic proliferation, is still missing. Here, we use a previously in-house developed computational EC-adapted genome scale metabolic model that recapitulat...
2026-08-10 | MTBLS15306 | MetaboLights
MetabolomicsEMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer

The involvement of membrane-bound solute carriers (SLCs) in neoplastic transdifferentiation processes is poorly defined. Here, we examined changes in the SLC landscape during epithelial-mesenchymal transition (EMT) of pancreatic cancer cells. We show that two SLCs from the organic anion...

2021-10-15 | MTBLS1925 | MetaboLights
ProteomicsYBX3 is a versatile RNA-binding protein that controls amino acid import by regulating SLC mRNA abundance
Summary: Amino acids (AA) support protein synthesis, and thus cell growth and proliferation. Specialized transporters mediate AA exchange across membranes and their regulation is critical for AA homeostasis. Here, we report that the DNA- and RNA-binding protein YBX3 regulates the expression of AA t...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-11-06 | MSV000083108 | MassIVE
MetabolomicsEvaluation of Seryl-leucine core 1 O-glycosylated peptide (SLC1G) in TB patient urine
Not available
ORGANISM(S): Homo sapiens 
ST001069 | MetabolomicsWorkbench
MetabolomicsHypothalamic SLC7A14 accounts for aging-reduced lipolysis in white adipose tissue

The central nervous system has been implicated in the age-induced reduction in adipose tissue lipolysis. SLC7A14 is a lysosomal membrane protein highly expressed in the brain. Herein, we investigated the possible role of hypothalamic SLC7A14 in the age-induced lipolysis reduction. In this study, ...

2024-07-23 | MTBLS9872 | MetaboLights
ProteomicsInteraction proteomics of the human solute carrier (SLC) transporter superfamily
Solute carrier (SLC) transporters form a major superfamily which transport a wide range of substrates across cellular and organellar membranes. The superfamily consists of about 450 members and includes passive transporters, antiporters and symporters. To ensure the homeostatic regulation of metabol...
ORGANISM(S): Homo sapiens (Human) 
2025-03-03 | PXD055605 | Pride
Ppi resource Human slc Ap-ms Large-scale ap-ms 
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