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TranscriptomicsLinkage of Meis1 leukemogenic activity to multiple downstream effectors including Trib2 and Ccl3
OBJECTIVE: MEIS1, a HOX cofactor, collaborates with multiple HOX and NUP98-HOX fusion proteins to accelerate the onset of acute myeloid leukemia (AML) through largely unknown molecular mechanisms. MATERIALS AND METHODS: To further resolve these mechanisms, we conducted a structure-function analysis ...
ORGANISM(S): Mus musculus 
2009-04-09 | E-GEOD-15541 | biostudies-arrayexpress
TranscriptomicsGene expression changes induced by overexpression of IDH1mut in the sorted mouse bone marrow cells
Mutations in the enzymes IDH1 and IDH2 have been identified in a wide variety of tumors like glioma, chondrosarcoma, thyroid cancer, lymphoma, melanoma, and in acute myeloid leukemia. Mutated IDH1/2 produces the metabolite 2-hydroxyglutarate (2HG), which interferes with epigenetic regulation of gene...
ORGANISM(S): Mus musculus 
2013-11-05 | E-GEOD-45019 | biostudies-arrayexpress
UnknownQueensland Family Cohort: a study protocol.
Not available
S-EPMC8231060 | biostudies-literature
UnknownA large-scale, consortium-based genomewide association study of asthma.
Not available
S-EPMC4260321 | biostudies-literature
UnknownGenome-wide association and large-scale follow up identifies 16 new loci influencing lung function.
Not available
S-EPMC3267376 | biostudies-literature
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