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TranscriptomicsThe Multicopy Gene Sly Represses the Sex Chromosomes in the Male Mouse Germline after Meiosis part 2
Studies of mice with Y chromosome long arm deficiencies suggest that the male-specific region (MSYq) encodes information required for sperm differentiation and postmeiotic sex chromatin repression (PSCR). Several genes have been identified on MSYq, but because they are present in more than 40 copies...
ORGANISM(S): Mus musculus 
2011-05-11 | E-GEOD-29200 | biostudies-arrayexpress
TranscriptomicsThe Multicopy Gene Sly Represses the Sex Chromosomes in the Male Mouse Germline after Meiosis
Studies of mice with Y chromosome long arm deficiencies suggest that the male-specific region (MSYq) encodes information required for sperm differentiation and postmeiotic sex chromatin repression (PSCR). Several genes have been identified on MSYq, but because they are present in more than 40 copies...
ORGANISM(S): Mus musculus 
2011-05-11 | E-GEOD-29198 | biostudies-arrayexpress
TranscriptomicsDeficiency in the multicopy Sycp3-like X-linked genes Slx and Slxl1 causes major defects in spermatid differentiation
The gene Sly is present in multiple copies on the mouse Y chromosome and encodes a protein that is required for the epigenetic regulation of postmeiotic sex chromosome expression. The X chromosome carries two multicopy genes related to Sly: Slx and Slxl1. Here we investigate the role of Slx/Slxl1 us...
ORGANISM(S): Mus musculus 
2011-05-11 | E-GEOD-29197 | biostudies-arrayexpress
TranscriptomicsA genetic basis for a postmeiotic X vs. Y chromosome intragenomic conflict in the mouse
The Y-encoded multicopy gene Sly has been shown to repress X and Y genes in spermatids, among which are its X-linked homologs Slx and Slxl1, via modulation of post-meiotic sex chromain (PMSC). In this experiment, we compared expression in spermatids from mice that are deficient for Sly (shSLY), for ...
ORGANISM(S): Mus musculus 
2012-07-05 | E-GEOD-39109 | biostudies-arrayexpress
TranscriptomicsGlobal expression profiling of CD4 T-cell responses to house dust mite allergens in human atopics and nonatopics.
The aim of this study was to employ a systems-level analysis to elucidate gene expression networks operating in the CD4 T-cell responses which underpin human atopic disease. Keywords: Disease state analysis; T-cell response The study design consisted of 45 subjects, including 30 HDM-sensitized atop...
ORGANISM(S): Homo sapiens 
2009-05-05 | E-GEOD-14908 | biostudies-arrayexpress
TranscriptomicsIn utero exposure to arsenic via drinking water impairs lung development and mucociliary clearance genes.
In utero exposure to arsenic via drinking water increases the risk of lower respiratory tract infections during infancy and mortality from bronchiectasis in adulthood. Pregnant mice were exposed to arsenic, and gene expression patterns were profiled in peripheral lung tissue obtained from the offspr...
ORGANISM(S): Mus musculus 
2013-06-04 | E-GEOD-37831 | biostudies-arrayexpress
TranscriptomicsImmune response eQTL study in human neonatal myeloid cells and T cells
Gene expression microarray data in resting myeloid cells and CD4+ T cells, as well as in response to lipopolysaccharide (LPS) or phytohemagglutinin (PHA) stimulation for 24 hours, respectively. Myeloid cells and CD4+ T cells were purified from resting and stimulated peripheral blood mononuclear cell...
ORGANISM(S): Homo sapiens 
2020-04-20 | E-MTAB-8977 | biostudies-arrayexpress
UnknownmRNA vaccines encoding membrane-anchored RBDs of SARS-CoV-2 mutants induce strong humoral responses and can overcome immune imprinting.
Not available
S-EPMC11646785 | biostudies-literature
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