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ProteomicsIn vitro phosphorylation of trypsin-digested K562 cell lysate by TAM family kinases
K562 cell lysate was digested with trypsin, dephosphorylated with lambda phosphatase, and treated in an in vitro kinase reaction with Axl, Mer or Tyro3 kinase, alongside a control reaction for each that contained no kinase. Samples were phosphoenriched with the SMOAC approach (TiO2 and FeNTA) and an...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-08-29 | MSV000092784 | MassIVE
ProteomicsIdentification of RIOK2 as a master regulator of human blood cell development
Myelodysplastic syndromes (MDS) are a group of hematologic neoplasms in which the bone marrow fails to produce enough mature blood cells, leading to peripheral blood cytopenias and myeloproliferation1-3. The average survival time following diagnosis of MDS is 2.5 years4, owing to few treatment optio...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-10-16 | MSV000088238 | MassIVE
TranscriptomicsH2AZ extended acidic patch is necessary for formation specialized chromatin states in ESCs [RNA-Seq]
The H2A variant H2AZ is essential for embryonic development and for proper execution of developmental gene expression programs in embryonic stem cells (ESCs). Divergent regions in H2AZ are likely key for its functional specialization, but we know little about how these differences contribute to chro...
ORGANISM(S): Mus musculus 
2013-09-23 | E-GEOD-40064 | biostudies-arrayexpress
GenomicsH2AZ extended acidic patch is necessary for formation specialized chromatin states in ESCs
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-09-23 | E-GEOD-40065 | biostudies-arrayexpress
GenomicsH2AZ extended acidic patch is necessary for formation specialized chromatin states in ESCs [ChIP-Seq]
The H2A variant H2AZ is essential for embryonic development and for proper execution of developmental gene expression programs in embryonic stem cells (ESCs). Divergent regions in H2AZ are likely key for its functional specialization, but we know little about how these differences contribute to chro...
ORGANISM(S): Mus musculus 
2013-09-23 | E-GEOD-40063 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of imprint free mouse mouse embryonic stem (IF-ES) cells vs wild type MEFs
Loss of imprinting (LOI), commonly observed in human tumors, refers to loss of monoallelic gene regulation normally conferred by parent-of-origin specific DNA methylation. To test the function of LOI in tumorigenesis, we developed a model using transient demethylation to generate imprint-free mouse ...
ORGANISM(S): Mus musculus 
2005-10-20 | E-MEXP-450 | biostudies-arrayexpress
TranscriptomicsPRC2 coordinates lineage fidelity and DNA methylation during ESC differentiation (RNA-Seq)
Polycomb Repressive Complex 2 (PRC2) catalyzes histone H3 lysine 27 tri-methylation, an epigenetic modification associated with gene repression. H3K27me3 is enriched at the promoters of a large cohort of developmental genes in embryonic stem cells (ESCs). Loss of H3K27me3 leads to a failure of ESCs ...
ORGANISM(S): Mus musculus 
2014-11-17 | E-GEOD-53506 | biostudies-arrayexpress
UnknownctDNA response after pembrolizumab in non-small cell lung cancer: phase 2 adaptive trial results.
Not available
S-EPMC10579094 | biostudies-literature
UnknownA phase I dose-escalation and pharmacokinetic study of sunitinib in combination with pemetrexed in patients with advanced solid malignancies, with an expanded cohort in non-small cell lung cancer.
Not available
S-EPMC3286593 | biostudies-literature
UnknownAfatinib versus gefitinib in patients with EGFR mutation-positive advanced non-small-cell lung cancer: overall survival data from the phase IIb LUX-Lung 7 trial.
Not available
S-EPMC5391700 | biostudies-literature
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