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MetabolomicsCharacterization of small intracellular vesicles uncovers their potential as drug carriers and therapeutic agents

Small extracellular vesicles (sEVs) have been extensively investigated as a source of clinically relevant cargo. Alongside the secretion of EVs, such as exosomes, cells house a multitude of internal vesicles involved in various physiologic processes and metabolic activities. Herein, we developed ...

2025-09-02 | MTBLS12923 | MetaboLights
MetabolomicsmiR-9394b from Lactobacillus paracasei extracellular vesicles targets iNOS to reprogram host NO-ornithine metabolism and ameliorate ulcerative colitis

Background Probiotics have attracted considerable interest for ulcerative colitis (UC); however, their efficacy is highly strain-specific and the underlying molecular mechanisms remain incompletely understood.

Results Accumulating evidence indicates that bacterial extracellular vesicles (BE...

2026-01-23 | MTBLS13753 | MetaboLights
TranscriptomicsmiRNA expression of extracellular vesicles
To further investigate the molecular mechanisms by which EVs mediated the abnormal localization of tight junction proteins and adherence junction protein, we performed miRNA microarray analysis of extracellular vesicles isolated from breast cancer cells. miRNA expression in extracellular vesicles wa...
ORGANISM(S): Homo sapiens 
2015-04-02 | E-GEOD-63445 | biostudies-arrayexpress
TranscriptomicsSmall RNA sequencing of plasma extracellular vesicles from HIV/HCV coinfected patients
We have analyzed six different extracelular vesicles isolation protocols from plasma of patients coinfected with human immunodeficiency virus and hepatitis C virus (HIV/HCV). In addition, two different RNA isolation kit were used for each protocol, one phenol-based and another pehenol-free kit. Same...
ORGANISM(S): Homo sapiens 
2020-08-14 | E-MTAB-8246 | biostudies-arrayexpress
TranscriptomicsExtracellular Vesicles in Luminal Fluid of the Ovine Uterus
Exosomes/microvesicles (hereafter referred to as extracellular vesicles) were isolated from the ULF of day 14 cyclic and pregnant ewes using ExoQuick-TC. Extracellular vesicle RNA was pooled (n=4 per status) and analyzed for small RNAs by sequencing on the Ion Torrent PGM platform and analysis with ...
ORGANISM(S): Ovis aries 
2014-01-11 | E-GEOD-53974 | biostudies-arrayexpress
TranscriptomicsCharacterization of the small RNA content of Trypanosoma cruzi extracellular vesicles
A growing body of evidence in mammalian cells indicates that secreted vesicles can be used to mediate intercellular communication processes by transferring various bioactive molecules, including mRNAs and microRNAs. Based on these findings, we decided to analyze whether T. cruzi-derived extracellula...
ORGANISM(S): Trypanosoma cruzi 
2014-07-15 | E-GEOD-54111 | biostudies-arrayexpress
TranscriptomicsMicroarray of neural progenitor cells from neonatal lung injury mice treated with placebo or umbilical-cord mesenchymal stromal cell extracellular vesicles or untreated, as well as age-matched control mice
The purpose of this experiment was to determine the transcriptional differences between neural progenitor cells from neonatal lung injury mice vs. control mice, as well as neonatal lung injury mice treated with umbilical-cord mesenchymal stromal cell extracellular vesicles vs. neonatal lung injury m...
ORGANISM(S): Mus musculus 
2022-05-17 | E-MTAB-11157 | biostudies-arrayexpress
TranscriptomicsComparative transcriptomic analysis of human and Drosophila extracellular vesicles reveals extensive conservation
Extracellular vesicles (EVs) are membrane-enclosed nanoparticles containing specific repertoires of genetic material. In mammals, EVs can mediate the horizontal transfer of various cargos and signaling molecules, notably miRNA and mRNA species. Whether this form of intercellular communication prevai...
ORGANISM(S): Homo sapiens 
2016-06-15 | E-GEOD-76173 | biostudies-arrayexpress
TranscriptomicsmRNA expression of brain endothelial cells
To investigate the mRNA expression after extracellular vesicles or miRNA treatement, global gene expression analysis was performed in endothelial cells after the transfection of N.C. or miR-181c and or after the addition of extracellular vesicles from cancer cells. mRNA expression in brain endotheli...
ORGANISM(S): Macaca fascicularis 
2015-04-02 | E-GEOD-63447 | biostudies-arrayexpress
TranscriptomicsmiRNA content in extracellular vesicles
comparison miRNA content between extracellular vesicles from AAV-transduced or intact cells
ORGANISM(S): Rattus norvegicus 
2021-08-07 | E-MTAB-10858 | biostudies-arrayexpress
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