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MetabolomicsStrong effect of Penicillium roqueforti populations on volatile and metabolic compounds responsible for aromas, flavour and texture in blue cheeses
Studies of food microorganism domestication can provide important insight into adaptation mechanisms and lead to commercial applications. Penicillium roqueforti is a fungus with four genetically differentiated populations, two of which were independently domesticated for blue cheese-making, with the...
2021-10-06 | MTBLS1509 | MetaboLights
MetabolomicsCirculating cell populations as response predictors and targets to improve immunotherapy in metastatic lung cancer

The effectiveness of immunotherapy varies among patients with advanced non-small cell lung cancer (NSCLC). Here we investigated the baseline immune status in stage IV NSCLC patients treated with anti-PD-1 plus chemotherapy to understand the immune mechanisms and unveil systemic markers associated...

2025-10-16 | MTBLS13150 | MetaboLights
TranscriptomicsCharacterization of unique small RNA populations from rice grain
Small RNAs (~20 to 24 nucleotides) function as naturally occurring molecules critical in developmental pathways in plants and animals. Here we analyze small RNA populations from mature rice grain and seedlings by pyrosequencing. Using a clustering algorithm to locate regions producing small RNAs, w...
ORGANISM(S): Oryza sativa 
2008-11-24 | E-GEOD-13152 | biostudies-arrayexpress
MetabolomicsConnecting structure and function from organisms to molecules in small-animal symbioses through chemo-histo-tomography
Our understanding of metabolic interactions between small symbiotic animals and bacteria or parasitic eukaryotes that reside within their bodies is extremely limited. This gap in knowledge originates from a methodological challenge, namely to connect histological changes in host tissues induced by b...
2021-07-06 | MTBLS2639 | MetaboLights
TranscriptomicsDivergent Patterns of Endogenous Small RNA Populations From Seed and Vegetative Tissues of Glycine max
An overview of small RNAs sequences existing in seed development and contrasted with vegetative tissues of the soybean Four small RNA sequence populations from high throughput deep sequencing-by-synthesis and representing different tissues/organs of the soybean were characterized into small RNA cla...
ORGANISM(S): Glycine max 
2012-10-09 | E-GEOD-36728 | biostudies-arrayexpress
ProteomicsA Signal Amplification via Boosting with Isobaric Labeling Strategy for Comprehensive Quantitative Phosphoproteomic Characterization of Small Populations of Cells
Despite recent advances in MS-based proteomics, comprehensive phosphoproteomics analysis of small populations of cells remains a daunting task, due primarily to the general lack of sufficient MS signals from such limited amounts of samples. In light of the unique multiplexing feature of isobaric lab...
ORGANISM(S): Homo Sapiens (human) 
2019-03-15 | PXD011857 | JPOST Repository
TranscriptomicsSmall RNA pyrosequencing in the protozoan parasite Entamoeba histolytica reveals strain-specific small RNAs that target virulence genes
We provided a full spectrum analysis for E. histolytica AGO2-2 associated 27nt small RNAs. Additionally, comparative analysis of small RNA populations from virulent and non-virulent amebic strains indicates that small RNA populations may regulate virulence genes. AGO2-2 bound small RNAs from E. hist...
ORGANISM(S): Entamoeba histolytica 
2013-01-24 | E-GEOD-43668 | biostudies-arrayexpress
TranscriptomicsSmall RNAs in Chlamydomonas reinhardtii
RNA populations in Chlamydomonas reinhardtii Keywords: Highly parallel pyrosequencing Small RNAs were prepared from Chlamydomonas reinhardtii total extracts,ligated to a 3' adaptor and a 5' acceptor sequentially, and then RT-PCR amplified. PCR products were reamplified using a pair of 454 cloning pr...
ORGANISM(S): Chlamydomonas reinhardtii 
2007-05-15 | E-GEOD-7308 | biostudies-arrayexpress
TranscriptomicsA diverse set of microRNAs and microRNA-like small RNAs in developing rice grains
Endogenous small RNAs, including microRNAs (miRNAs) and short-interfering RNAs (siRNAs), function as posttranscriptional or transcriptional regulators in plants. miRNA function is essential for normal development and therefore likely to be important in the growth of the rice grain. To investigate th...
ORGANISM(S): Oryza sativa 
2008-08-21 | E-GEOD-11014 | biostudies-arrayexpress
TranscriptomicsSequencing of microRNA in spermatogonial stem cell enriched cell populations.
MicroRNAs (miRs) play a key role in the control of gene expression in a wide array of tissue systems where their functions include the regulation of self-renewal, cellular differentiation, proliferation, and apoptosis. However, the functional importance of individual miRs in controlling spermatogoni...
ORGANISM(S): Mus musculus 
2011-07-20 | E-GEOD-29613 | biostudies-arrayexpress
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