Sort   by:  
 Page size 
MetabolomicsStress-related mitogen-activated protein kinases stimulate the accumulation of small molecules and proteins in Arabidopsis thaliana root exudates
A delicate balance in cellular signaling is required for plants to distinguish mutualist from parasitic organisms in its environment. Mitogen-activated protein kinase (MAPK) cascades are one of the signaling modules that mediate transduction of extracellular microbial signals into appropriate cellul...
2017-08-25 | MTBLS441 | MetaboLights
MetabolomicsCharacterization of the heat-stable proteome during seed germination in Arabidopsis with special focus on LEA proteins
During seed germination, desiccation tolerance is lost in the radicle with progressing radicle protrusion and seedling establishment. This process is accompanied by comprehensive changes of the metabolome and proteome. Germination of Arabidopsis seeds was investigated over 72 h with special focus on...
2021-07-29 | MTBLS2980 | MetaboLights
MetabolomicsA Prototypic Small Molecule Database for Bronchoalveolar Lavage-Based Metabolomics
The analysis of bronchoalveolar lavage fluid (BALF) using mass spectrometry-based metabolomics can provide insight into lung diseases, such as asthma. However, the important step of compound identification is hindered by the lack of a small molecule database that is specific for BALF. Here we descri...
2018-02-09 | MTBLS591 | MetaboLights
MetabolomicsCharacterization of small intracellular vesicles uncovers their potential as drug carriers and therapeutic agents

Small extracellular vesicles (sEVs) have been extensively investigated as a source of clinically relevant cargo. Alongside the secretion of EVs, such as exosomes, cells house a multitude of internal vesicles involved in various physiologic processes and metabolic activities. Herein, we developed ...

2025-09-02 | MTBLS12923 | MetaboLights
MetabolomicsJejunal inflammatory cytokines, barrier proteins and microbiome-metabolome responses to early supplementary feeding of Bamei suckling piglets

BACKGROUND: Dietary intervention has been reported to improve intestinal health. The intestinal microbiota of newborn animals plays a fundamental role in the development of intestinal function and the innate immune system. However, little is currently known about dietary interven...

2020-06-05 | MTBLS1698 | MetaboLights
MetabolomicsChanges in L-phenylalanine concentration reflect and predict response to anti-PD-1 treatment combined with chemotherapy in patients with non-small cell lung cancer
Chemotherapy combined with checkpoint blockade antibodies targeting programmed cell death protein (PD-1) has achieved remarkable success in non-small cell lung cancer (NSCLC). However, few patients benefit from long-term treatment. Therefore, biomarkers capable of guiding the optimal therapeutic sel...
2025-06-16 | MTBLS11232 | MetaboLights
MetabolomicsApoptosis-inducing effects of aqueous extract of Eleutherococcus senticosus on non-small cell lung cancer cell proliferation

Non-small cell lung cancer is a malignant tumor with high morbidity and mortality worldwide. Eleutherococcus senticosus can induce apoptosis in non-small cell lung cancer cells, but the mechanism remains unclear. This study aimed to elucidate the role of Eleutherococcus senticosus in inducing apo...

2025-05-12 | MTBLS10545 | MetaboLights
MetabolomicsAssociation Study on the Regulation of Muscle Development-Related Genes, Proteins, and Metabolites in Different Parts by Gastrointestinal Flora During Various Developmental Stages of Liaoning Cashmere Goats

Introduction: Muscle growth and development in Liaoning cashmere goats (a dual-purpose breed for cashmere and meat) and its regulation by intestinal flora are key to improving meat production, yet relevant molecular mechanisms remain unclear.

Objectives: To reveal the molecular mechanism ...

2025-10-30 | MTBLS12972 | MetaboLights
MetabolomicsAttenuate host susceptibility to respiratory virus invasion by inhibiting interactions between host proteins SLC16A3 and AP1G1

Modulating cell endocytosis activity to reduce host susceptibility to virus represents a promising strategy for antiviral drug development. In this study, we reveal that lactate transporter SLC16A3 as a critical host factor for reducing diverse virus invasion. By performing metabolomics, proteomi...

2025-07-28 | MTBLS12788 | MetaboLights
TranscriptomicsSequence, Biogenesis, and Function of Diverse sRNA Classes Bound to the Piwi-family Proteins of Tetrahymena thermophila
PAZ/PIWI-domain (PPD) proteins carrying small RNAs (sRNAs) function in gene and genome regulation. The ciliate Tetrahymena thermophila encodes numerous PPD proteins exclusively of the Piwi clade. We show that the three Tetrahymena Piwi-family proteins (Twis) preferentially expressed in growing cells...
ORGANISM(S): Tetrahymena thermophila 
2009-11-23 | E-GEOD-17006 | biostudies-arrayexpress
Sort   by:  
 Page size