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TranscriptomicsEvidence that Loading of Cohesin Onto Chromosomes Involves Opening of Its SMC Hinge
Cohesin is a multisubunit complex that mediates sister-chromatid cohesion. Its Smc1 and Smc3 subunits possess ABC-like ATPases at one end of 50 nm long coiled coils. At the other ends are pseudosymmetrical hinge domains that interact to create V-shaped Smc1/Smc3 heterodimers. N- and C-terminal domai...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-09 | E-GEOD-4827 | biostudies-arrayexpress
GenomicsMycobacterium sp. SMC-4
Mycobacterium sp. SMC-4 Genome sequencing
PRJNA745503 | ENA
GenomicsMycobacterium sp. SMC-2
Mycobacterium sp. SMC-2 Genome sequencing
PRJNA745498 | ENA
GenomicsMycobacterium sp. SMC-8
Mycobacterium sp. SMC-8 Genome sequencing
PRJNA745500 | ENA
GenomicsATAC-seq in paired SMC vs. Non-SMC
ATAC-seq in paired SMC vs. Non-SMC
PRJNA664053 | ENA
GenomicsStreptomyces antimicrobicus strain:SMC 277
Streptomyces antimicrobicus strain:SMC 277 Genome sequencing and assembly
PRJNA770026 | ENA
GenomicsDifferential gene expression in paired SMC vs. Non-SMC
Differential gene expression in paired SMC vs. Non-SMC
PRJNA664763 | ENA
GenomicsEnterococcus sp. SMC-9
Enterococcus sp. SMC-9 Genome sequencing and assembly
PRJNA755342 | ENA
GenomicsControl of Smc Coiled Coil Architecture by the ATPase Heads Facilitates Targeting to Chromosomal ParB/parS and Release onto Flanking DNA
Smc/ScpAB promotes chromosome segregation in prokaryotes, presumably by compacting and resolving nascent sister chromosomes. The underlying mechanisms, however, are poorly understood. Here, we investigate the role of the Smc ATPase activity in the recruitment of Smc/ScpAB to the Bacillus subtilis ch...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2016-02-18 | E-GEOD-76949 | biostudies-arrayexpress
GenomicsThe Mediator MED23 plays opposing roles in directing smooth muscle cell and adipocyte differentiation
The Mediator complex functions as a control center orchestrating diverse signalings, gene activities, and biological processes. However, how Mediator subunits determine distinct cell fates remains to be fully elucidated. Here, we show that Mediator MED23 controls the cell fate preference that direct...
ORGANISM(S): Mus musculus 
2012-12-20 | E-GEOD-40369 | biostudies-arrayexpress
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