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TranscriptomicsCpG island methylation data from maternal venous blood and infant cord blood samples
The biological mechanism of cadmium's effects is poorly characterized. This data was generated in order to help better understand the epigenetic role that Cadmium plays. We used the MIRA assay and the Affymetrix Human Promoter 1.0R Array in order to measure methylation levels in promoter regions. 34...
ORGANISM(S): Homo sapiens 
2015-04-17 | E-GEOD-67976 | biostudies-arrayexpress
TranscriptomicsExpression data from TK6 exposed to low-dose metals
We are investigating the response of human lymphoblastoid cells to low-dose exposure of environmental metals We used microarrays to detail the global programme of gene expression upon response to low-dose metals Keywords: dose TK6 cells were grown to mid log-phase and exposed to low-doses of arsen...
ORGANISM(S): Homo sapiens 
2010-04-14 | E-GEOD-20320 | biostudies-arrayexpress
TranscriptomicsmRNA expression data from A549 exposed to fresh or aged urban air mixtures
We are investigating the mRNA expression profiles of human lung cells to gaseous urban mixtures We used microarrays to compare the global mRNA expression profiles upon response to fresh against aged urban mix Keywords: dose A549 cells were grown to confluency and exposed to fresh urban mix, aged ur...
ORGANISM(S): Homo sapiens 
2011-02-01 | E-GEOD-23735 | biostudies-arrayexpress
TranscriptomicsEpigenetics and Preeclampsia: Defining Functional Epimutations in the Preeclamptic Placenta Related to the TGF-β Pathway [methylation]
Placental Tissue Samples from 36 women (17 normotensive women, denoted with a P, and 19 preeclamptic women, denoted with a Q) were analyzed for differenital methylation Preeclamptic womene were compared direclty to normotensive women controlling for gestational age, race, maternal age, and baby sex ...
ORGANISM(S): Homo sapiens 
2015-09-24 | E-GEOD-73375 | biostudies-arrayexpress
TranscriptomicsEpigenetics and Preeclampsia: Defining Functional Epimutations in the Preeclamptic Placenta Related to the TGF-β Pathway [gene expression]
Placental Tissue Samples from 36 women (17 normotensive women, denoted with a P, and 19 preeclamptic women, denoted with a Q) were analyzed for differenital methylation Preeclamptic womene were compared direclty to normotensive women controlling for gestational age, race, maternal age, and baby sex ...
ORGANISM(S): Homo sapiens 
2015-09-24 | E-GEOD-73374 | biostudies-arrayexpress
TranscriptomicsPrenatal arsenic exposure and the epigenome: Identifying sites of 5-methyl cytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes
Prenatal exposure to inorganic arsenic (iAs) is detrimental to the health of newborns and increases the risk of disease development later in life. Here we examined a subset of newborn cord blood leukocyte samples collected from mothers enrolled in the Biomarkers of Exposure to ARsenic (BEAR) pregnan...
ORGANISM(S): Homo sapiens 
2014-11-03 | E-GEOD-62924 | biostudies-arrayexpress
TranscriptomicsDNA methylation data from nasal epithelial cells of human smokers and nonsmokers
We are investigating the methylation profiles associated with cigarette smoke exposure. We used arrays to compare the DNA methylation profiles in healthy human smokers and nonsmokers. Nasal epithelial cells were extracted from 12 volunteers (6 smokers, 6 nonsmokers), and grown until fully differenti...
ORGANISM(S): Homo sapiens 
2011-06-01 | E-GEOD-28368 | biostudies-arrayexpress
TranscriptomicsFormaldehyde-induced changes in microRNA signaling [Affymetrix]
In addition to gaining knowledge on in vivo miRNA responses to formaldehyde, we set out to relate these miRNA responses to transcriptional profiles modified by formaldehyde. Rats were exposed by inhalation to either 0 or 2 ppm formaldehyde (6 hours/day) for 28 days. Genome-wide transcriptional profi...
ORGANISM(S): Rattus norvegicus 
2014-01-07 | E-GEOD-42394 | biostudies-arrayexpress
TranscriptomicsFormaldehyde-induced changes in microRNA signaling [Agilent]
MicroRNAs (miRNAs) are critical regulators of gene expression, yet much remains unknown regarding miRNA changes resulting from environmental exposures and whether they influence pathway signaling across various tissues and time. To gain knowledge on these novel topics, we set out to investigate in v...
ORGANISM(S): Rattus norvegicus 
2014-01-07 | E-GEOD-42393 | biostudies-arrayexpress
TranscriptomicsEpigenetics effects of formaldehyde inhalation exposure
We set out to test the hypothesis that formaldehyde inhalation exposure significantly alters miRNA expression profiles within the nasal epithelium of nonhuman primates. Here, cynomolgus macaques were exposed to 0, 2, and 6 ppm formaldehyde for 6 hours/day across two consecutive days. RNA was extract...
ORGANISM(S): Macaca fascicularis 
2012-09-01 | E-GEOD-34978 | biostudies-arrayexpress
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