Sort   by:  
 Page size 
TranscriptomicsMH003A:FOXO3 in control of circadian rhythms via direct regulation of Clock. Part 1: overexpression of FoxO6
Circadian rhythms are responsive to a variety of external cues, light and metabolism being the most important. In mammals, the light signal is sensed by the retina and transmitted to the SCN master clock, where it is translated into the molecular oscillator via regulation of clock gene transcription...
ORGANISM(S): Mus musculus 
2014-06-03 | E-GEOD-41554 | biostudies-arrayexpress
TranscriptomicsMH003B:FOXO3 in control of circadian rhythms via direct regulation of Clock. Part 2: knockdown of FoxO3.
Circadian rhythms are responsive to a variety of external cues, light and metabolism being the most important. In mammals, the light signal is sensed by the retina and transmitted to the SCN master clock, where it is translated into the molecular oscillator via regulation of clock gene transcription...
ORGANISM(S): Mus musculus 
2014-06-03 | E-GEOD-41555 | biostudies-arrayexpress
TranscriptomicsKC002-EH005: Genetic and epigenetic features of induced pluripotent stem cell-derived dopaminergic neurons
Induced pluripotent stem cells (iPSCs) hold great promise for in vitro disease modeling and cell replacement therapy for Parkinson’s disease (PD). Both applications crucially require an in-depth profiling of the disease-relevant, iPSC-derived cell type. Midbrain dopaminergic (mDA) neurons derived fr...
ORGANISM(S): Mus musculus 
2014-05-13 | E-GEOD-47178 | biostudies-arrayexpress
TranscriptomicsFJ001: Retinoic acid-dependent and -independent gene-regulatory pathways of Pitx3 in meso-diencephalic dopaminergic neurons
Development of meso-diencephalic dopamine (mdDA) neurons requires the combined actions of the orphan nuclear receptor Nurr1 and the paired-like homeobox transcription factor Pitx3. Whereas all mdDA neurons require Nurr1 for expression of Th and survival, dependence on Pitx3 is only displayed by the ...
ORGANISM(S): Mus musculus 
2011-11-22 | E-GEOD-32940 | biostudies-arrayexpress
TranscriptomicsEH004: Lmx1a encodes a rostral set of mesodiencephalic dopaminergic neurons marked by the Wnt/b-catenin signaling activator Rspo2
Recent developments in molecular programming of mesodiencephalic dopaminergic (mdDA) neurons have led to the identification of many transcription factors playing a role in mdDA specification. LIM homeodomain transcription factor Lmx1a is essential for chick mdDA development, and for the efficient di...
ORGANISM(S): Mus musculus 
2013-12-13 | E-GEOD-45831 | biostudies-arrayexpress
Sort   by:  
 Page size