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TranscriptomicsRole of the extracytoplasmic-function sigma Factor sigmaH in Mycobacterium tuberculosis global gene expression
Like other bacterial species, Mycobacterium tuberculosis has multiple sigma (s) factors encoded in its genome. In previously published work, we and others have shown that mutations in some of these transcriptional activators render M. tuberculosis sensitive to various environmental stresses and, in ...
ORGANISM(S): Mycobacterium tuberculosis 
2007-08-03 | E-GEOD-8689 | biostudies-arrayexpress
MetabolomicsCTH exacerbates Helicobacter pylori immunopathogenesis by promoting macrophage metabolic remodeling and activation
Macrophages play a crucial role in the inflammatory response to the human stomach pathogen Helicobacter pylori, which infects half of the world's population and causes gastric cancer. Recent studies have highlighted the importance of macrophage immunometabolism in their activation state and function...
2022-06-14 | MTBLS2851 | MetaboLights
TranscriptomicsRNA-seq of wild type Pseudomonas protegens CHA0 and H-NS-like mutants ΔmvaT, ΔmvaV and ΔmvaTΔmvaV
A RNA-seq was used to test the effect of two DNA-damaging agents (mitomycin C and hydrogen peroxide) on gene expression in wild type Pseudomonas protegens CHA0 and three H-NS-like mutants: ΔmvaT, ΔmvaV and ΔmvaTΔmvaV.
ORGANISM(S): Pseudomonas protegens 
2025-04-02 | E-MTAB-14715 | biostudies-arrayexpress
MetabolomicsHypusination Orchestrates the Antimicrobial Response of Macrophages
Innate responses of myeloid cells defend against pathogenic bacteria via inducible effectors. Deoxyhypusine synthase (DHPS) catalyzes the transfer of the N-moiety of spermidine to the lysine-50 residue of eukaryotic translation initiation factor 5A (EIF5A) to form the amino acid hypusine. Hypusinate...
2021-04-06 | MTBLS607 | MetaboLights
TranscriptomicsArray results for differential gene expression in 661W, a mouse cone photoreceptor-derived cell line, comparing cells incubated with vehicle controls vs. those treated with either of two 7-dehdyrocholesterol-derived oxysterols or cholesterol
RELEVANCE: Smith-Lemli-Opitz syndrome (SLOS) is a human disease caused by mutations in the gene coding for the enzyme DHCR7 (7-dehydrocholesterol (7DHC) reductase), which catalyzes the final step of cholesterol biosynthesis. Accumulated 7DHC in tissues and body fluids of SLOS patients gives rise t...
ORGANISM(S): Mus musculus 
2021-03-20 | E-MTAB-10055 | biostudies-arrayexpress
UnknownDiverse actions of sirtuin-1 on ovulatory genes and cell death pathways in human granulosa cells.
Not available
S-EPMC9284863 | biostudies-literature
TranscriptomicsTranscription profiling of Mycobacterium tuberculosis wild type and sigH mutant strains after exposure to the thiol-specific oxidizing agent diamide
Like other bacterial species, Mycobacterium tuberculosis has multiple sigma (s) factors encoded in its genome. In previously published work, we and others have shown that mutations in some of these transcriptional activators render M. tuberculosis sensitive to various environmental stresses and, in ...
ORGANISM(S): Mycobacterium tuberculosis 
2007-09-12 | E-TABM-316 | biostudies-arrayexpress
TranscriptomicsGenomic comparison of virulent Rickettsia rickettsii Sheila Smith and avirulent Rickettsia rickettsii Iowa
Comparison of gene expression between the virulent Rickettsia rickettsii R strain and avirulent Rickettsia rickettsii Iowa. Keywords: virulent vs avirulent Virulent Rickettsia rickettsii R strain in triplicate was compared to avirulent Rickettsia rickettsii Iowa in triplicate
ORGANISM(S): Rickettsia rickettsii 
2010-05-26 | E-GEOD-8041 | biostudies-arrayexpress
TranscriptomicsPatterns of dioxin-altered mRNA expression in livers of dioxin-sensitive versus dioxin-resistant rats
The dioxin congener 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes a wide range of toxic effects in rodent species, all of which are mediated by a ligand-dependent transcription-factor, the aryl hydrocarbon receptor (AHR). The Han/Wistar (Kuopio) (H/W) strain shows exceptional resistance to many ...
ORGANISM(S): Rattus norvegicus 
2011-11-14 | E-GEOD-13513 | biostudies-arrayexpress
UnknownReduced Endothelin-2 and Hypoxic Signaling Pathways in Granulosa-Lutein Cells of PCOS Women.
Not available
S-EPMC8347025 | biostudies-literature
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