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TranscriptomicsNatural variation in Arabidopsis thaliana transcriptomes
A major effort is underway to study the natural variation within the model plant species, Arabidopsis thaliana. Much of this effort is focused on genome resequencing, however the translation of genotype to phenotype will be largely effected through variations within the transcriptomes at the sequen...
ORGANISM(S): Arabidopsis thaliana 
2012-05-21 | E-GEOD-38109 | biostudies-arrayexpress
GenomicspiRNA pathway targets active LINE1 elements to establish repressive H3K9me3 mark in germ cells
Transposable elements (TEs) occupy large fraction of metazoan genomes and pose constant threat to genomic integrity. This threat is particularly critical in germ cells, as changes in the genome that are induced by TEs will be transmitted to the next generation. Small non-coding piwi interacting (pi)...
ORGANISM(S): Mus musculus 
2014-06-13 | E-GEOD-58332 | biostudies-arrayexpress
TranscriptomicsTransposable elements and small RNAs contribute to gene expression divergence between Arabidopsis thaliana and Arabidopsis lyrata
This SuperSeries is composed of the following subset Series: GSE24571: Transposable elements and small RNAs contribute to gene expression divergence between Arabidopsis thaliana and Arabidopsis lyrata [RNA-Seq] GSE38109: Natural variation in Arabidopsis thaliana transcriptomes Refer to individual Se...
ORGANISM(S): Arabidopsis thaliana 
2012-05-21 | E-GEOD-38113 | biostudies-arrayexpress
GenomicsGenome-wide ChIP seq analysis of Aspergillus nidulans reveals deregulation of fungal nitrogen metabolism triggered by Streptomyces rapamycinicus
Mining of fungal genomes uncovered their great potential for the production of novel secondary metabolites (SMs). However most of them stay silent under standard laboratory cultivation conditions. Co-cultivation of fungi with organism that occur in their natural habitat has shown to be trigger for t...
ORGANISM(S): Aspergillus nidulans 
2018-10-12 | E-MTAB-5819 | biostudies-arrayexpress
TranscriptomicsMIWI2 and MILI have differential effects on piRNA biogenesis and DNA methylation
In developing male germ cells, prospermatogonia, two Piwi proteins, MILI and MIWI2, use piRNA guides to repress transposable element (TE) expression and ensure genome stability and proper gametogenesis. In addition to their roles in post-transcriptional TE repression, both proteins are required for ...
ORGANISM(S): Mus musculus 
2015-07-11 | E-GEOD-70731 | biostudies-arrayexpress
TranscriptomicsMethylation profiling of glioblastoma neural stem cells and reprogrammed derivatives
Glioblastoma-derived neural stem (GNS) cells were reprogrammed to induced pluripotent stem (iPS) cells by transgenic expression of OCT4 and KLF4. Genome-wide DNA methylation status was profiled at 27,578 CpG sites to assess epigenetic erasure and restoration due to reprogramming and redifferentiatio...
ORGANISM(S): Homo sapiens 
2013-03-15 | E-MTAB-1275 | biostudies-arrayexpress
TranscriptomicsHigh-resolution methylation profiling of glioblastoma neural stem cells and reprogrammed derivatives
Glioblastoma-derived neural stem (GNS) cells were reprogrammed to induced pluripotent stem (iPS) cells by transgenic expression of OCT4 and KLF4. Genome-wide DNA methylation status was profiled at 485,000 loci to assess epigenetic erasure and restoration due to reprogramming and redifferentiation to...
ORGANISM(S): Homo sapiens 
2013-03-15 | E-MTAB-1274 | biostudies-arrayexpress
GenomicsReleasing activity disengages cohesin’s Smc3/Scc1 interface in a process blocked by acetylation
Sister chromatid cohesion conferred by entrapment of sister DNAs within a tripartite ring formed between cohesin’s Scc1, Smc1, and Smc3 subunits is generated during S and eventually destroyed at anaphase through cleavage of Scc1 by separase. Throughout the cell cycle, cohesin’s association with ...
ORGANISM(S): Saccharomyces cerevisiae 
2016-02-18 | E-GEOD-76890 | biostudies-arrayexpress
UnknownThe PREDICTS database: a global database of how local terrestrial biodiversity responds to human impacts.
Not available
S-EPMC4278822 | biostudies-literature
UnknownThe database of the PREDICTS (Projecting Responses of Ecological Diversity In Changing Terrestrial Systems) project.
Not available
S-EPMC5215197 | biostudies-literature
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