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GenomicsMouse ooplasm confers context-specific reprogramming capacity
Enucleated oocytes have the remarkable ability to reprogram somatic nuclei back to totipotency. Here we investigate genome-scale DNA methylation patterns after nuclear transfer and identify specific targets for DNA demethylation as well as NT specific limitations. We find that the ooplasm can confer...
ORGANISM(S): Mus musculus 
2012-08-10 | E-GEOD-38711 | biostudies-arrayexpress
GenomicsDNA methylation dynamics of the human pre-implantation embryo
We present genome-scale maps of DNA methylation in early human development and perform comparative analysis to mouse that confirm a conserved global erasure of the paternal genome. We find that while many global features of the early embryo are consistent between the two species, the target sequenc...
ORGANISM(S): Mus musculus 
2014-07-23 | E-GEOD-51239 | biostudies-arrayexpress
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