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MetabolomicsExamining the effects of cigarette smoke on mouse lens through a multi OMIC approach
Here, we report a multi OMIC (transcriptome, proteome, and metabolome) approach to investigate molecular changes in lens fiber cells (FC) of mice exposed to cigarette smoke (CS). Pregnant mice were placed in a whole-body smoke chamber and a few days later pups were born, which were exposed to CS for...
2024-03-24 | MTBLS207 | MetaboLights
MetabolomicsComprehensive systems biology analysis of a seven-month cigarette smoke inhalation study in C57BL/6 mice
Smoking of combustible cigarettes has a major impact on human health. Using a systems toxicology approach in a model of chronic obstructive pulmonary disease (C57BL/6 mice), we assessed the health consequences in mice of smoke derived from a prototype modified risk tobacco product (pMRTP) as compare...
2015-11-19 | MTBLS143 | MetaboLights
MetabolomicsMulti-omics systems toxicology study of mouse lung assessing the effects of aerosols from two heat-not-burn tobacco products and cigarette smoke
Cigarette smoke (CS) causes adverse health effects and leads to the development of respiratory disease (chronic obstructive pulmonary disease), cardiovascular disease, and cancer. To reduce the risk of smokers developing smoking-related diseases, Philip Morris International is developing modified ri...
2020-04-25 | MTBLS158 | MetaboLights
TranscriptomicsWhole DNA methylome profiling in mice exposed to secondhand smoke
A large body of evidence has linked secondhand smoke (SHS) to lung cancer in nonsmokers. Yet, the underlying mechanisms of SHS carcinogenicity in nonsmokers' lung cancer remain elusive. Recently, we have demonstrated a genotoxic mode of action for SHS, based on the ability of this carcinogen to indu...
ORGANISM(S): Mus musculus 
2012-11-29 | E-GEOD-41421 | biostudies-arrayexpress
MetabolomicsObesity and Poor Diet as Susceptibility Factors for Secondhand Smoke in Childhood Asthma
Not available
ORGANISM(S): Homo sapiens 
ST001325 | MetabolomicsWorkbench
MetabolomicsBiological Responses to Tobacco Smoke Exposure in III Children: Inflammatory Processes and the Oral Microbiome
Not available
ORGANISM(S): Homo sapiens 
ST001200 | MetabolomicsWorkbench
ProteomicsDissecting the molecular effects of cigarette smoke on proteasome function
Proteasome dysfunction is emerging as a novel pathomechanism for the development of chronic obstructive pulmonary disease (COPD), a major leading cause of death in the world. Cigarette smoke is one of the main risk factors for COPD and has been shown to impair proteasome function in vitro and in viv...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2019-01-08 | PXD007148 | Pride
Cigarette smoke Proteasome 
MetabolomicsThe impact of tobacco smoke exposure and environmental exposures on the pulmonary microbiome of critically ill children
Not available
ORGANISM(S): Homo sapiens 
ST001262 | MetabolomicsWorkbench
ProteomicsSmooth Muscle Cell Phenotypic Switch Induced by Cigarette Smoke Condensate
Cigarette smoke is a risk factor for inflammatory diseases, such as atherosclerosis. Tobacco smoke interacts with inflammatory cytokines to produce endothelial dysfunction and induces pro-inflammatory and pro-atherosclerotic effects in vascular tissue. Smooth muscle cells (SMCs) are present in the m...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD041174 | Pride
Atherosclerosis  cigarette smoke  electronic cigarette  phenotypic switch  smooth muscle cells 
MetabolomicsEarly Mechanistic Events Induced by Secondhand Smoke Prevalent Low Molecular Weight Polycyclic Aromatic Hydrocarbons in Mouse Lung Epithelial Cells
Not available
ORGANISM(S): Mus musculus 
ST001124 | MetabolomicsWorkbench
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