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Vascular smooth muscle cells (VSMCs) respond to biomechanical stretch with specific changes in gene expression which govern the phenotype of these cells. The mechanotransducer zyxin is a potential candidate for regulating the expression of such genes. Using microarrays, we compared stretch-induced ...
ORGANISM(S): Mus musculus 
Compared the gene expression profiles of human vascular smooth muscle cells in response to cyclical mechanical strain over a time course of 2, 4 and 24 hours to examine temporal pattern of gene expression in response to strain.
ORGANISM(S): Homo sapiens 
Background: Human genetic discovery studies have implicated ADAMTSL4 as a putative susceptibility locus for spontaneous coronary artery dissection (SCAD). Although biallelic ADAMTSL4 variants cause ectopia lentis via impaired fibrillin microfibril assembly the vascular consequences of heterozygous A...
ORGANISM(S): Homo sapiens (Human) 
2026-10-06 | PXD083670 | Pride
Actin polymerization can regulate smooth muscle gene expression but the full extent of this regulation is unknown. To understand the full impact of actin polymerization on smooth muscle gene expression cells were cultured with the actin stabilizing drug jasplakinolide for 24h. Mouse aortic smooth mu...
ORGANISM(S): Mus musculus 
Pharmacological activation of the transcription factor PPAR gamma lowers blood pressure and improves glucose tolerance in humans. In contrast, naturally occurring mutations (e.g., P467L, V290M) in the ligand binding domain of PPAR gamma in humans leads to severe insulin resistance and early-onset h...
ORGANISM(S): Mus musculus 
Pharmacological activation of the transcription factor PPAR gamma lowers blood pressure and improves glucose tolerance in humans. In contrast, naturally occurring mutations (e.g., P467L, V290M) in the ligand binding domain of PPAR gamma in humans leads to severe insulin resistance and early-onset h...
ORGANISM(S): Mus musculus 
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