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TranscriptomicsIL-33 induces a hypo-responsive human mast cell phenotype
Interleukin-33 (IL-33) is elevated in afflicted tissues of patients with mast cell-dependent chronic allergic diseases. Based on its acute effects on mouse mast cells (MCs), IL-33 is thought to play a role in the pathogenesis of allergic disease through MC activation. However, the manifestations of ...
ORGANISM(S): Mus musculus 
2013-02-06 | E-GEOD-39382 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-seq of JBT19 - a novel PD-L1- and collagen-expressing patient-derived cell line of undifferentiated pleomorphic sarcoma as a model for cancer immunotherapy
In this study, we characterized the cellular homogeneity of a novel patient-derived undifferentiated pleomorphic sarcoma (UPS) cell line, JBT19. The JBT19 cells express PD-L1 and collagen, a ligand of the immune checkpoint molecule LAIR-1. JBT19 cells can form 3D spheroids in vitro and solid tumors ...
ORGANISM(S): Homo sapiens 
2024-01-31 | E-MTAB-12758 | biostudies-arrayexpress
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