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MetabolomicsSnail reprograms glucose metabolism by repressing PFKP allowing cancer cell survival under metabolic stress
Dynamic regulation of glucose flux between aerobic glycolysis and the pentose phosphate pathway (PPP) during epithelial-mesenchymal transition (EMT) is not well-understood. Here we show that Snail (SNAI1), a key transcriptional repressor of EMT, regulates glucose flux toward PPP, allowing cancer cel...
2017-11-07 | MTBLS387 | MetaboLights
TranscriptomicsRetinoic acid induces Snai1 in stem cells of the preimplantation blastocyst to initiate differentiation
Although much is known about the pluripotency self-renewal circuitry, the molecular events that lead embryonic stem cells (ESCs) exit from pluripotency and begin differentiation are largely unknown. We found that the zinc finger transcription factor Snai1, involved in gastrulation and epithelial- me...
ORGANISM(S): Mus musculus 
2015-01-12 | E-GEOD-57854 | biostudies-arrayexpress
TranscriptomicsDm Snail Affymetrix ChIP
Genomewide mapping of D. melanogaster Snail protein binding during embryonic development at 2-4 hrs after egg-laying. Two independent repeats were assayed and preimmune-serum was used as a control. The enriched DNA was hybridized to high density Affymetrix GeneChip Drosophila Tiling 1.0R array
ORGANISM(S): Drosophila melanogaster 
2014-01-10 | E-MTAB-1589 | biostudies-arrayexpress
TranscriptomicsD. melanogaster gene expression profiling time course of Snail mutants
Expression profiling of Drosophila melanogaster halo[AJ] snail[Df(2L)TE116GW11] and halo[AJ] sna[V2] homozygous mutant embryos at two timepoints of embryogenesis. Embryos were manually sorted and assayed at cellularisation stage (stage 5 to early stage 6) and at gastrulation stage (late stage 6 to e...
ORGANISM(S): Drosophila melanogaster 
2014-01-10 | E-MTAB-1598 | biostudies-arrayexpress
TranscriptomicsSynergy between plasminogen activator inhibitor-1 and Snail in tumoral migration
Snail, a family of transcriptional repressors implicated in cell movement, has been correlated with tumour invasivity. The Plasminogen Activation system (PAs), including urokinase (uPA), its receptor (uPAR), and its inhibitor (PAI-1), also plays a key role in cancer invasion and metastasis, either t...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-10395 | biostudies-arrayexpress
ProteomicsDeciphering the impact of ectopic SNAI1 expression on renal tubular cell proteome and functions
Snail1 is crucial in regulating epithelial mesenchymal transition (EMT), which leads to excessive extracellular matrix (ECM) production and organ fibrosis including the kidney. Elucidating the roles of snail1 in EMT and kidney fibrosis is thus vital for developing targeted therapies. This study inve...
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD061033 | Pride
Renal fibrosis Senescence Proteomics Snail1 Kidney 
TranscriptomicsRNA-seq data of si-Snai1, si-Snai2, si-Snai1/2 and si-Scrambled treated mouse primary myoblasts
In skeletal myogenesis, the transcription factor MyoD, activates distinct transcriptional programs in progenitors compared to terminally differentiated cells. Using ChIP-seq and gene expression analyses, we show that in primary myoblasts, Snai1/2-HDAC1/2 repressive complex bind and exclude MyoD from...
ORGANISM(S): Mus musculus 
2012-07-04 | E-GEOD-38236 | biostudies-arrayexpress
TranscriptomicsExpression data from differentiating Flk1- and Flk1+ ES cells expressing Snail during Wnt inhibition
ES cells differentiated in the presence of the Wnt inhibitor DKK1 fail to express the transcription factor Snail and undergo EMT or mesoderm differentiation. We generated an ES cell line, A2.snail, that induced Snail expression upon addition of doxycycline addition. Microarrays were used to gain a ...
ORGANISM(S): Mus musculus 
2013-10-23 | E-GEOD-26524 | biostudies-arrayexpress
TranscriptomicsSNAI1 induced epithelial to mesenchymal transition miRNA study in time course
To identify miRNAs participating in SNAI1-orchestrated regulatory pathways, we analysed time-resolved microarray data of SNAI1-induced EMT, obtained during conditional expression of SNAI1 in a “Tet-Off” MCF7-SNAI1 breast carcinoma cell model (Vetter et al, 2009). miRNA time series study for 7 times ...
ORGANISM(S): Homo sapiens 
2012-01-13 | E-GEOD-35074 | biostudies-arrayexpress
TranscriptomicsExpression data from control (F/F) and Snai1 knockout (KO) embryoid body (EB) and teratoma ™
Snai1 is a master factor of epithelial to mesenchymal transitioin (EMT), however, its role in embryonic stem cell (ESC) differentiation and lineage commitment remains undefined. We used microarrays to compare the global programme of gene expression between control and Snai1 knockout ESCs-derived EB ...
ORGANISM(S): Mus musculus 
2013-12-10 | E-GEOD-53106 | biostudies-arrayexpress
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