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MetabolomicsOrganic and Peptidyl Constituents of Snake Venoms: The Picture Is Vastly More Complex Than We Imagined
Small metabolites and peptides in 17 snake venoms (Elapidae, Viperinae, and Crotalinae), were quantified using liquid chromatography-mass spectrometry. Each venom contains >900 metabolites and peptides. Many small organic compounds are present at levels that are probably significant in prey envenoma...
2023-01-11 | MTBLS755 | MetaboLights
ProteomicsA snapshot of Bothrops jararaca snake venom gland subcellular proteome
The synthesis of snake venom proteins is subjected to finely regulated processes in the specialized secretory epithelium within the venom gland. Such processes occur within a defined time frame in the cell and at specific cellular locations. Thus, the determination of subcellular proteomes allows th...
ORGANISM(S): Bothrops jararaca (Jararaca) (Bothrops jajaraca) 
2023-09-30 | PXD040239 | Pride
Bothrops jararaca Snake venom Snake venom gland Proteome Subcellular fractionation 
ProteomicsQualitative and quantitative analysis of Bothrops jararaca venom gland proteome
While cellular transcripts encode rich information that provide key features to understand the molecular basis of snake venom variation, their presence/ abundance does not necessary imply/correlate in the translation of a functional (protein) product. In this study we carried out an analysis of the ...
ORGANISM(S): Bothrops jararaca (Jararaca) (Bothrops jajaraca) 
2016-09-28 | PXD004186 | Pride
Venom gland proteome Snake venom proteome Bothrops jararaca Venom variability 
ProteomicsPhysiological constraints dictate toxin spatial heterogeneity in snake venom glands
Venoms are ecological innovations that have evolved numerous times, on each occasion accompanied by the co-evolution of specialised morphological and behavioural characters for venom production and delivery. The close evolutionary interdependence between these characters is exemplified by animals th...
ORGANISM(S): Calloselasma rhodostoma Naja nigricollis Naja subfulva 
2022-06-10 | PXD034174 | Pride
Venom Evolution Mass spectrometry imaging Venom gland 
ProteomicsSnake Venom LC/MSE - Post-transcriptional Mechanisms Contribute Little to Phenotypic Variation in Snake Venoms
Protein expression is a major link in the genotype-phenotype relationship, and processes affecting protein abundances, such as rates of transcription and translation, could contribute to phenotypic evolution if they generate heritable variation. Recent work has suggested that mRNA abundances do not ...
ORGANISM(S): Micrurus fulvius (Eastern coral snake) (Coluber fulvius) Sistrurus miliarius barbouri (Dusky pigmy rattlesnake) (Sistrurus barbouri) Crotalus horridus (Timber rattlesnake) Crotalus adamanteus (Eastern diamondback rattlesnake) Hypsiglena jani Sistrurus catenatus (massasauga) Agkistrodon contortrix Boiga irregularis (Brown tree snake) Micrurus tener (Texas coral snake) Agkistrodon piscivorus (cottonmouth) 
2015-11-09 | PXD002837 | Pride
Snake venom Lc/mse 
ProteomicsGenus wide venom proteomics of cobras (Naja)
Genus-wide proteomics analysis of cobra (Naja) venoms. For top-down analysis, venom samples were reduced with TCEP and measured via HPLC-MS/MS (Q-Exactive) . Spectrum-Protein matching was performed with TopPic1.1 against a genus wide translated transcriptome database and NCBI protein entries from th...
ORGANISM(S): Naja (ncbitaxon:8638) 
2018-01-04 | MSV000081885 | MassIVE
ProteomicsAssessing Target Specificity of the Small Molecule Inhibitor Marimastat to Snake Venom Toxins: A Novel Application of Thermal Proteome Profiling
New treatments that circumvent the pitfalls of traditional antivenom therapies are critical to address the problem of snakebite globally. Numerous snake venom toxin inhibitors have shown promising cross-species neutralization of medically significant venom toxins in vivo and in vitro. The developmen...
ORGANISM(S): Crotalus atrox 
2024-06-22 | PXD046399 | Pride
Thermal proteome profiling Snake venom Metalloprotease 
ProteomicsCharacterization of extracellular vesicles from Bothrops jararaca snake venom
Venoms are important evolutionary keys and innovation for several animal taxons., including snakes. Their use is specially related to feed, predation and defense. Snake venoms are composed mainly by free secreted proteins, about 98%, and stored in the lumen of the venom gland, where they are process...
ORGANISM(S): Bothrops jararaca (Jararaca) (Bothrops jajaraca) 
2023-03-10 | PXD037375 | Pride
Extracellular vesicles Snake venom 
TranscriptomicsRNA sequencing of venom glands and venom gland organoids
Both single cell and bulk RNA sequencing was performed on expanding or differentiating snake venom gland organoids (from Aspidelaps Lubricus Cowlesi and Naja Nivea), or tissue (Aspidelaps Lubricus Cowlesi). Bulk RNA sequencing from the snake venom gland, liver and pancreas was performed to construct...
ORGANISM(S): Naja nivea Aspidelaps lubricus cowlesi 
2020-02-24 | GSE129581 | GEO
GenomicsRNA sequencing of venom glands and venom gland organoids
RNA sequencing of venom glands and venom gland organoids
PRJNA531889 | ENA
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