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MetabolomicsSNAP25 inhibits glioma progression by regulating synapse plasticity via GLS-mediated glutaminolysis

INTRODUCTION: Neuronal activity regulated by synaptic communication exerts an important role in tumorigenesis and progression in brain tumors. Genes for soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) annotated with the function ‘vesicle’ about syn...

2021-08-12 | MTBLS2806 | MetaboLights
GenomicsUpregulation of SNAP25 by HDAC inhibition ameliorates NPC disease phenotypes via autophagy induction
Upregulation of SNAP25 by HDAC inhibition ameliorates NPC disease phenotypes via autophagy induction
PRJNA770263 | ENA
TranscriptomicsSynapTRAP on SNAP25 TRAP Cortex
SynapTRAP. Identification of Synaptic mRNA of neurons of the cortex. Technique combines sucrose percoll fractionation of a synaptically rich sample (SN) and TRAP tagged ribosome IP (PreIP and PostIP). This experiment uses pan neuronal SNAP25 mice and a cortical dissection.
ORGANISM(S): Mus musculus 
2017-08-14 | GSE74506 | GEO
TranscriptomicsUpregulation of SNAP25 by HDAC inhibition ameliorates NPC disease phenotypes via autophagy induction
Niemann-Pick Type C disease (NPC) is a rare fatal neurodegenerative disorder caused by mutations in NPC1 and NPC2 gene leading to abnormal accumulation of unesterified cholesterol in lysosomes. There have been no available treatments and FDA approved drugs for treating NPC. SAHA, a HDAC inhibitor (H...
ORGANISM(S): Homo sapiens 
2024-09-26 | GSE185644 | GEO
UnknownDifferential palmitoylation regulates intracellular patterning of SNAP25.
Not available
S-EPMC3065388 | biostudies-literature
TranscriptomicsDetection of lower levels of SNAP25 using multiple microarray systems and its functional significance in medulloblastoma
Medulloblastoma (MB) is the most common pediatric malignant brain tumor and patients with a high-risk or recurrent MB respond poorly to current therapies, with higher related mortality. Potential molecules related to MB must be identified to develop targets for therapeutic development. In the presen...
ORGANISM(S): Homo sapiens 
2015-11-13 | GSE74947 | GEO
UnknownDual functions of SNAP25 in mouse taste buds.
Not available
S-EPMC12369304 | biostudies-literature
GenomicsTRAP-seq from hippocampus isolated from WT and Fmr1-/y mice bred to Snap25-EGFPL10a mice
TRAP-seq from hippocampus isolated from WT and Fmr1-/y mice bred to Snap25-EGFPL10a mice
PRJNA819407 | ENA
UnknownSNAP25 is a potential prognostic biomarker for prostate cancer.
Not available
S-EPMC8991690 | biostudies-literature
TranscriptomicsComparison of translational profiles in Motor Neurons (CHAT), to all neurons (Snap25) in the spinal cord.
Translating ribosome affinity purification (TRAP) was performed on spinal cord dissections pooled from 3-4 mice 21 days post birth that were positive for the eGFP-L10A fusion ribosomal marker protein under the expression of either the Chat promoter (Tg(Chat-EGFP/Rpl10a)DW167Htz) or the Snap25 promot...
ORGANISM(S): Mus musculus 
2017-06-20 | GSE93412 | GEO
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