Sort   by:  
 Page size 
TranscriptomicsFocal Adhesion Kinase Dependent Expression
The goal of this study was to identify transcripts, which are differentially regulatulated in the presence and absence of Focal Adhesion Kinase. As Focal Adhesion Kinase activity can depend upon cell density (Snijder et al. Nature 2009), biological replicates where cells, were seeded very sparsely o...
ORGANISM(S): Mus musculus 
2013-09-17 | E-GEOD-43873 | biostudies-arrayexpress
TranscriptomicsProfile of gene expression in U87-MG xenografts expressing control vector (V0), the ubiquitin ligase KPC1 or the p50 subunit of the NF-kB transcription factor, using RNASeq analysis of transcripts mapped independently to the human and murine genomes
Purpose: We identified KPC1 as the ubiquitin ligase that binds to the p105 precursor of NF-kB, ubiquitinates it and mediates its proteasomal processing to generate the p50 active subunit of the transcription factor. Using U87-MG human glioblastoma xenografts, we observed that overexpression of KPC1 ...
ORGANISM(S): Homo sapiens 
2015-04-09 | E-GEOD-60530 | biostudies-arrayexpress
TranscriptomicsWnt directs the endosomal flux of LDL-derived cholesterol and lipid droplet homeostasis
The Wnt pathway, which controls crucial steps of the development and differentiation programs, has been proposed to influence lipid storage and homeostasis. In this paper, using an unbiased strategy based on high content genome-wide RNAi screens that monitored lipid distribution and amounts, we find...
ORGANISM(S): Homo sapiens 
2015-06-20 | E-MTAB-2872 | biostudies-arrayexpress
ProteomicsEx vivo drug response heterogeneity reveals personalized therapeutic strategies for patients with multiple myeloma
Multiple myeloma (MM) is a plasma cell malignancy defined by complex genetics and extensive patient heterogeneity. Despite a growing arsenal of approved therapies, MM remains incurable and in need of guidelines to identify effective personalized treatments. Here, we survey the ex vivo drug and immun...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-03-06 | MSV000088992 | MassIVE
ProteomicsHCOV-NL63 spike protein glycopeptides
HCoV-NL63 is a coronavirus that can cause severe lower respiratory tract infections requiring hospitalization. Of great interest is understanding the HCoV-NL63 coronavirus spike glycoprotein trimer, which is the conformational machine responsible for entry into host cells and the sole target of neut...
ORGANISM(S): Human Coronavirus Nl63 (ncbitaxon:277944) 
2020-03-13 | MSV000085098 | MassIVE
MetabolomicsGNPS Metabolomics analysis of 180 cancer cell lines
Metabolome analysis of 180 cancer cell lines. Intracellular extracts. Flow injection analysis - TOF (negative mode, no LC). Sample description is included in Metadata_File_CellLines.txt
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-04-04 | MSV000087155 | GNPS
ProteomicsHigh-throughput identification of repurposable neuroactive drugs with potent anti-glioblastoma activity
Glioblastoma, the most aggressive primary brain cancer, has dismal prognosis, yet systemic treatment is limited to DNA-alkylating chemotherapies. New therapeutic strategies may emerge from exploring neurodevelopmental and neurophysiological vulnerabilities of glioblastoma. To this end, we here syste...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000090357 | MassIVE
Sort   by:  
 Page size