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Here, we report the genome-wide analysis of snRNAs that are bound to Gemin5 upon protein synthesis inhibition. Upon protein synthesis inhibition, the SMN complex that has a crucial role in the biogenesis of snRNPs dissociates into its subunits, leaving Gemin5 alone. The existence of these subunits w...
ORGANISM(S): Homo sapiens 
snRNAs as regulators of alternative splicing
Substoichiometric ribose methylations in spliceosomal snRNAs
Exogenous signals from drug-stressed cancer cells accelerate the proliferation of neighboring tumor cells and promote them to acquire a more aggressive phenotype. We have recently found an exciting phenomenon: drug-stressed cancer cells secrete various components of the spliceosome: proteins and a n...
ORGANISM(S): Homo sapiens (Human) 
2024-05-29 | PXD027950 | Pride
Effect of extracellular spliceosomal snRNAs on the transcriptome of ovarian cancer cells
RiboMeth-Seq analysis of purified U6 and U2 snRNAs
In this study we investigated snRNA-mediated modulation of pre-mRNA splicing across the human transcriptome. We first quantified the relative abundance of snRNAs across a comprehensive range of healthy adult and fetal tissues, revealing a surprising variation in the relative snRNA levels both inter-...
ORGANISM(S): Homo sapiens 
2018-12-31 | GSE107163 | GEO
Variant U1 snRNAs contribute to cell cycle and differentiation control of human iPS cells
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