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MetabolomicsPathogenic NLRP3 mutants form constitutively active inflammasomes resulting in immune-metabolic limitation of IL-1β production

BACKGROUND: Cryopyrin-Associated Periodic Syndrome (CAPS) is an autoinflammatory condition consequence of monoallelic variants in the NLRP3 gene that exacerbate IL-1β production. These variants are gain-of-function, but the exact regulatory mechanism of the NLRP3 CAPS-inflammasom...

2024-01-09 | MTBLS7872 | MetaboLights
TranscriptomicsDuctal Carcinoma Progression
To obtain insight into the molecular basis of ductal carcinoma in situ (DCIS) and its progression by infiltrating surrounding tissue, we have performed cellular-based gene expression analysis of pure DCIS and DCIS with co-existing invasive ductal carcinoma (IDC) and compared the histological and mol...
ORGANISM(S): Homo sapiens 
2008-04-04 | E-GEOD-11042 | biostudies-arrayexpress
UnknownComparative evaluation of infected and noninfected Amblyomma triste ticks with Rickettsia parkeri, the agent of an emerging rickettsiosis in the New World.
Not available
S-EPMC3722777 | biostudies-literature
UnknownA cluster randomized trial of a multifaceted quality improvement intervention in Brazilian intensive care units: study protocol.
Not available
S-EPMC4342101 | biostudies-literature
TranscriptomicsTranscription profiling of mycelium and yeast cells of Paracoccidioides brasiliensis
Identification of differential mRNAs produced in the mycelium and yeast cells of Paracoccidioides brasiliensis
ORGANISM(S): Paracoccidioides brasiliensis 
2004-04-28 | E-MEXP-103 | biostudies-arrayexpress
TranscriptomicsGene expression profile of classical Hodgkin lymphoma according to Epstein-Barr infection status
Transcriptional profiling of Human Hodkin Lymphoma lineages infected or not by Epstein Baar Virus (EBV). We compared EBV infected lineage L591 and not EBV infected lineages L428, L1236 and KMH2. Goal was to determine presence versus absence of EBV infection on global gene expression of Hodkin Lymp...
ORGANISM(S): Homo sapiens 
2011-12-31 | E-GEOD-21586 | biostudies-arrayexpress
UnknownA prognostic model for use before elective surgery to estimate the risk of postoperative pulmonary complications (GSU-Pulmonary Score): a development and validation study in three international cohorts.
Not available
S-EPMC12056793 | biostudies-literature
UnknownDelaying surgery for patients with a previous SARS-CoV-2 infection.
Not available
S-EPMC7537063 | biostudies-literature
UnknownGeneral and abdominal adiposity and hypertension in eight world regions: a pooled analysis of 837 population-based studies with 7·5 million participants.
Not available
S-EPMC7616775 | biostudies-literature
UnknownGeoeconomic variations in epidemiology, ventilation management, and outcomes in invasively ventilated intensive care unit patients without acute respiratory distress syndrome: a pooled analysis of four observational studies.
Not available
S-EPMC8766316 | biostudies-literature
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