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MetabolomicsMetabolic profiling of prostate cancer in skeletal microenvironments identifies G6PD as a key mediator of growth and survival

The spread of cancer to bone is invariably fatal, with complex cross-talk between tumor cells and the bone microenvironment responsible for driving disease progression. By combining in silico analysis of patient datasets with metabolomic profiling of prostate cancer cells cultured with bone cells...

2024-08-19 | MTBLS3973 | MetaboLights
TranscriptomicsmRNA expression in TTHA1939 deletion mutant of Thermus thermophilus HB8 strain grown on minimum medium
We compared the expression profile of TTHA1939 deletion mutant strain of Thermus thermophils HB8 with that of wild-type. The mutant strain grown in minimum essential medium (CS medium) exhibited growth arrest and cellular aggregation during the logarithm growth phase. In this phase, 99 genes were ...
ORGANISM(S): Thermus thermophilus HB8 
2010-05-22 | E-GEOD-8795 | biostudies-arrayexpress
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Cell NAMPTi treatment)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7251 | MetaboLights
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Mouse NAD targeted time-course)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7253 | MetaboLights
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Mouse NAMPT targeted therapy)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7252 | MetaboLights
TranscriptomicsMolecular studies on sex-different control of the hepatic metabolism in relations to insulin sensitivity (set 1)
In this study we have analyzed gene expression and metabolite levels in the livers of male and female Zucker diabetic fatty (ZDF) rats. We speculated that the sex different development of diabetes in the ZDF animals presents the opportunity to relate gender to diabetes (since only males become diabe...
ORGANISM(S): Rattus norvegicus 
2011-08-09 | E-GEOD-23808 | biostudies-arrayexpress
TranscriptomicsMolecular studies on sex-different control of the hepatic metabolism in relations to insulin sensitivity (set 2)
In this study we have analyzed gene expression and metabolite levels in the livers of male and female Zucker diabetic fatty (ZDF) rats. We speculated that the sex different development of diabetes in the ZDF animals presents the opportunity to relate gender to diabetes (since only males become diabe...
ORGANISM(S): Rattus norvegicus 
2011-08-09 | E-GEOD-23809 | biostudies-arrayexpress
ModelsYugi2014 - Insulin induced signalling (PFKL phosphorylation) - model 1
Yugi2014 - Insulin induced signalling (PFKL phosphorylation) - model 1 Insulin induces phosphorylation and activation of liver-type phosphofructokinase 1, which thereby controls a key reaction in glycolysis. This mechanism is revealed using the mathematical model. In this model, the PFKL ph...
2024-09-02 | BIOMD0000000540 | BioModels
ModelsYugi2014 - Insulin induced signalling (PFKL phosphorylation) - model 2
Yugi2014 - Insulin induced signalling (PFKL phosphorylation) - model 2 Insulin induces phosphorylation and activation of liver-type phosphofructokinase 1, which thereby controls a key reaction in glycolysis. This mechanism is revealed using the mathematical model. In this model, the PFKL ph...
2024-09-02 | BIOMD0000000541 | BioModels
TranscriptomicsTranscription profiling of S. cerevisiae and S. pastorianus harvested after 0, 6, 24, and 48 hrs of fermentation
S. cerevisiae S288C and S. pastorianus KBY011 were fermented at 20C for 48 hrs, respectively. The difference of transcription profiling between them was examined using samples harvested at 0, 6, 24, and 48 hrs during fermentation.
ORGANISM(S): Saccharomyces pastorianus 
2008-03-15 | E-MEXP-1086 | biostudies-arrayexpress
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